Posted by neuroman on September 22, 2005, at 12:35:33
In reply to Re: Provigil, Ritalin sinus infections HELP!, posted by florence on September 20, 2005, at 23:49:13
> I like to have documentation of the info I come across on line to print out to take to the dr whom I pay to treat me after I teach him/her about the mechanism of actions, etc. of these things. Sorry, I am not usually so sarcastic.
Believe me I know how you feel. Unfortunately, most doctors are clueless. Once they get their medical license they figure they know everything and that there's nothing left to learn. I better stop here because I'm about to go off on a tirade...
> SSRIs never worked for me. Ten yrs later I know why, thanks to this board. If u have a thyroid disease the ADs won't usually work until the thyroid problem is corrected. And mine was not even discovered for over ten yrs.
I've had a lot of the symptoms of low thyroid for many years along with a borderline high TSH, but was ignored until a thyroid antibody test was done about 9 months ago and I came back postive. I've been on 1/2 grain of mixed T3 T4 formula for about six months. Unfortunately it hasn't helped all that much.
> Do you use Scott's Pschiatric & Associated drug list?
Yes, it's an excellent reference.
> According to his list, buproprion has the property of being a ACh(n) antagonist-Is that the same thing as the NE alpha2 agonist in clonidine? ..I don't believe so.
According to my copy of "Essential Psychophamacology", bupropion (unlike the tricyclics) is not a direct Ach antagonist. However, since NE generally stimulates the sympathic nervous system and Ach is a major (if not the major) parasympathetic neurotransmitter, it may indirectly antagonize it. Scott (SLS) probably knows more about this than I do.
> Do u know how many types of NE receptors there are? alpha? beta?
Unless they've discovered some new ones, here they are (there may be beta subtypes too):
Alpha 1a, 1b, 1d, 2a, 2b, 2c, 2d and Beta 1 and 2.I'm still looking for a website or book that concisely describes the major functions of each of these receptors. Unfortunately, I get the impression that even the researchers aren't totally sure.
> I think I have anhedonia and dsythmia too as a result of my Hashimoto's thyroid disease. Depression and Fatigue are the hallmarks of this disease.
These can also be a sign of low dopamine. Especially the anhedonia. I know this is my main problem. Which would most likely also mean low norepinephrine levels. It's not a simple problem to address because generally in the face of chronically low neurotransmitter levels some of the receptors become sensitized.
> I am trying so hard to find something to supplement the provigil with so I don't get the tightness in the face and throbbing pressure in the ears...
Is this happening as it's wearing off?
By the way which wellbutrin were you on, regular, SR or XR? And for how long? I took a 100mg SR the day before yesterday. It didn't wipe me out. I had some of the sympathetic effects like piloerection (hair standing on end) and I have to say I felt really good yesterday. Maybe I'm a slow metabolizer and should take it every other day. We shall see...
Have you ever tried the amino acids phenylalanine or tyrosine? They are the dopamine and norepinephrine precursers. I take them everyday. They're no cure all but they help.
Keep me posted,
Paul
poster:neuroman
thread:546314
URL: http://www.dr-bob.org/babble/20050921/msgs/558138.html