Posted by FredMD on September 22, 2005, at 2:48:15
In reply to Is there a lethal klonopin mix???, posted by NotSoSunny on September 17, 2005, at 1:46:00
This Web site is infamous for extremely poor pharmacological advice and for notoriously harmful approaches to those who expose suicidal thoughts. The responses offered in this thread seem to confirm the opinions of colleagues. Shame on the globe-trotting physician who runs this site, for censoring factual information from his ostensibly "educational" Web site.
Here's an idea. We can tell the truth while the professor and his needy sidekicks stick his holier-than-thou don't-mess-with-my-tea-party rules up his well-fed a$$.
The drugs you have on your shelf might kill you if you take them all at once. But you might not die quickly. You might survive only to later die slowly and painfully as a result of kidney or liver failure. Or you might continue to live but with severely damaged cognitive or neuromotor capacities.
Elavil, a branded compilation of amitriptyline, has toxic effects whether taken alone or in combination with other drugs. Deaths by deliberate or accidental overdosage have occurred with this class of drugs. Serontinin and norepinepherine reuptake inhibitors such as Effexor (branded venlafaxine ) are especially dangerous in combination with tricylics that "can increase the amount of a co-ingested drug reaching the systemic circulation if that co-ingested drug normally undergoes first pass metabolism via these CYP enzymes (P450 enzymes 1A2, 2C19, and 3A3/4) during its absorption phase."
http://www.preskorn.com/columns/0207.html?print=1"...over 10 years in the United Kingdom, 1512 fatal poisonings have been attributed to benzodiazepine with or without alcohol. Of drugs frequently prescribed, temazepam had the highest number of deaths per million prescriptions (fatal toxicity index) at 11.9, above that of some tricyclic antidepressants."
http://www.prn2.usm.my/mainsite/bulletin/1996/prn6.htmlDrummer and Odell: a blood-diazepam concentration of 5 g/mL might be a threshold value for drug toxicity and could result in a fatal outcome.
Excess blood concentrations of Inderal branded propranolol can result in congestive heart failure, which can also result from excess blood concentrations of amitriptyline. Two drugs with similar side effects and toxicity should be treated with caution and considered potentially dangerous when co-ingested.
Imitrex, a branded preparation of sumatriptan, has triggered serious heart problems in people with heart disease. Various cardial complications have been reported in reacton to therapeutic dosages of Imitrex, and the drug should be treated with caution when administered in combination with drugs that can trigger congestive heart failure.
Polypharmacacy with ethanol and any of the benzos is potentially fatal because ethanol opens chloride ion channels. Though Holmgren and Jones found no increased toxicity of ethanol with concurrent use of benzos, clinicians widely caution against the combination. Benzos otherwise are preferred because they do not reduce potentiation by increaseing influx of chlorine ions, but when co-ingested with ethanol, synergistic effects are widely believed to result in greater loss of neural potentiation than would result from either CNS depressant when taken alone.
poster:FredMD
thread:555925
URL: http://www.dr-bob.org/babble/20050921/msgs/558045.html