Posted by SLS on June 13, 2005, at 22:12:41
In reply to Re: Amitriptyline - Therapeutic window or not » SLS, posted by Sarah T. on June 13, 2005, at 21:25:17
> > > > If you try reducing the dosage quickly, you might experience a reboud improvement that lasts a few hours to a few days.> - Scott
>
> Hi Scott.
>
> I have experienced this brief rebound improvement when withdrawing from TCA's. I would like to know why that happens. Do you know?No, but I bet the answer would yield a great clue as to why they work in the first place. I think it might involve forcing the system to establish a new equilibrium in response to a changing environment. Perhaps it takes a few hours to a few days for the receptors to respond to the new conditions after a dosage reduction. In the meantime, the brain tries to maintain a homeostasis built around a dysfunctional state. When it is successful, you relapse. When unsuccessful, you get well. I think this is why a drug like Tianeptine, a serotonin reuptake accelerator can mimick the effects of SSRIs, even though these drugs exert exactly the opposite effect at the synapse. It forces the system to compensate for either condition. Hopefully, when compensation occurs, the system will settle and reregulate itself and establish the dynamics according to the original genetic blueprint. This is just me thinking out loud.
- Scott
poster:SLS
thread:512207
URL: http://www.dr-bob.org/babble/20050611/msgs/512337.html