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Re: Seroquel and seratonin?? I am confused » Spriggy

Posted by Ritch on April 8, 2005, at 13:30:48

In reply to Seroquel and seratonin?? I am confused, posted by Spriggy on April 8, 2005, at 13:03:45

> I have read that Seroquel blocks dopamine and seratonin... is this right?
>
> This confuses me. Why would blocking those things be of help? Considering AD's do the reuptake those things to help you feel better.
>
> Could somebody explain this to me in 3rd grade terms??
>
> And if I was told to stay clear of things that mess with my seratonin- would that include things like Seroquel that apparently do mess with seratonin. OR did the pdoc just mean SSRI's?
>
> *confused blonde look*
>
> I want something to help this anxiety- the benzo's aren't cutting it. Doctor wants me on this Seroquel but when I take it, it gives me the weirdest heavy-head feeling.
>
> It's hard to describe but it's almost like I can feel my brain chemistry being FORCED To come to a complete HAULT. Like there is heavy furniture up there being forced to move. I know it's weird.. just go with me on this.
>
> Could someone please explain how this stuff works (and remember, talk to me like I'm an 8 year old). I don't understand words like 5ht antagonist/receptors and such. LOL
>
>

Hi, SSRI's block the "pumps" that remove serotonin, so it builds up and there's more of it. Seroquel blocks a serotonin "receptor" from "receiving" serotonin. Different mechanism, your pdoc probably meant not to mess with the SSRI's. I don't understand it all very well either. I took a small dose of Seroquel (25mg) at bedtime for a short while. The sluggish feeling is pretty intense on that one. To me it felt like trying to move through heavy transmission fluid or trying to swim in a pool full of jello. You might try only taking it at bedtime.. and even better take it about *2 hours* before bedtime, so it has a chance to wear off a little faster the next day, or get a pill cracker and take half a tab. Argh, if there's something I can't stand is being oversedated.


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