Posted by KaraS on February 24, 2005, at 15:57:22
In reply to Re: 5-HT2C receptor antagonists, posted by linkadge on February 24, 2005, at 15:23:50
> Both 5-ht2a and 5-ht2c "agonism" causes reduced dopamine in the prefrontal cortex.
>
> 5-ht2a/c anatagonists can reduce this effect and increase prefrontal dopamine release.
>
> 5-ht2a agonism can cause anxiety and insomnia, and 5-ht2c agonism generally causes sexual dysfunction and decreased apetite.
>
>
> However. Blocking the 5-ht2c receptor blocks the antidepressant effect of prozac. See the link...
>
> http://biopsychiatry.com/5ht2cantid.htm
>
> So 5-ht2c antagonism might reduce the AD effect of a drug.
>
> There is a lot over overlap between the 5-ht2a/c receptors and their clinical actions.
>
>
> Linkadge
>But wait, Prozac is a 5ht2c antagonist and it depresses dopamine overall. Is this because of the strong 5-ht reuptake inhibition?
k
poster:KaraS
thread:462559
URL: http://www.dr-bob.org/babble/20050222/msgs/462814.html