Posted by TheOutsider on January 17, 2005, at 6:44:22
In reply to Re: Which neurostransmitters affect social phobia?, posted by SLS on January 17, 2005, at 0:55:34
Personaly I suspect that Dopamine and GABA are the principal neuro transmitters which are disfunctional in Social Phobia.
GHB worked very well for my social phobia and it deffinetly works on GABA and Dopamine receptors, as well as having some effect on seratonin
Here is an Abstract that you might find interesting.
Low dopamine D(2) receptor binding potential in social phobia.
Schneier FR, Liebowitz MR, Abi-Dargham A, Zea-Ponce Y, Lin SH, Laruelle M.
Anxiety Disorders Clinic and the Brain Imaging Division, New York State Psychiatric Institute, New York 10032, USA. frs1@columbia.edu
OBJECTIVE: This study compared dopamine D(2) receptor binding potential in patients with social phobia and healthy comparison subjects. METHOD: Dopamine D(2) receptor binding potential was assessed in 10 unmedicated subjects with generalized social phobia and no significant lifetime psychiatric comorbidity and 10 healthy comparison subjects matched for age and sex. Binding potential was measured in the striatum by using single photon emission computerized tomography and constant infusion of the D(2) receptor radiotracer [(123)I]iodobenzamide ([(123)I]IBZM). RESULTS: Mean D(2) receptor binding potential was significantly lower in the subjects with social phobia than in the comparison subjects. Within the social phobia group, there was a nonsignificant correlation of binding potential with the Liebowitz Social Anxiety Scale score. CONCLUSIONS: Generalized social phobia may be associated with low binding of [(123)I]IBZM to D(2) receptors in the striatum.
PMID: 10698826 [PubMed - indexed for MEDLINE]
poster:TheOutsider
thread:442780
URL: http://www.dr-bob.org/babble/20050113/msgs/443062.html