Posted by btnd on September 19, 2004, at 5:24:09
Hi Michael!
> To attack SP, we must first understand it. First, a little DISCLAIMER - I know everybody's experience is different, but it seems highly evident to me that for most people with SP, there are three major problems: PHYSICAL SYMPTOMS OF ANXIETY/FEAR, WARPED MENTAL PERCEPTION and REWARD DEFICIENCY.
[...]
Great explanation of whole social phobia/anxiety disorder ! Really, one of the best I have ever read about and I totally agree with it (and I too have read, maybe not as much as you, but a lot about our disorder) :))
> SEROTONIN - I actually believe that with most people with SP, there is actually TOO MUCH serotonin transmission, or that the serotonin receptors are hypersensitive. Yes, serotonin is associated with wellbeing and social dominance, but too much is also associated in a plethora of studies with fear, harm avoidance and anxiety. I think that limiting the amount of serotonin being transmitted across the synapsis is actually beneficial for those with SP
> the TIANEPTINE is a Serotonin reptake ***enhancer***(meaning it decreases serotonin transmission)Are you 100% sure that Tianeptine, since its an "enhancer" - decreases serotonin transmission?
I'd just like to point that every time (5 times in my life) I tried MDMA (which in theory depletes serotonin during the experience) - I had a 2-3 day "after-glow" (the days after MDMA usage) which involved TOTAL ELIMINATION of social phobia + I was sociable and totally at ease in social situations (pro-social) even without any meds. I've always wondered why - your theory could explain it now.
> And this brings us to:
> ***CHOLECYTOSKININ (CCK)***: The more I read about CCK and CCK receptors in the brain, the more I believe this largely ignored peptide to be the missing link that ties all the elements of physical anxiety, learned fear and reward deficiency together. It is the most abundant peptide in the brain, and has been proven numerous times to have the following effects.
> - CCK is directly linked with fear conditioning
> - CCK agonists consistently elicit panic attacks in anxious and normal persons
> - CCK is essentially the anti-opioid, meaning it's effects are to neutralize opioids in the brain and body
> - CCK antagonists are extremely anxiolytic and neutralize the effects of anxiety-provoking substances
> - CCK levels skyrocket after people and animals experience social defeat
> - CCK has a modulatory effect on dopamine and is very important in the reward cascade
Very interesting. Do you know of any drugs that are CCK antagonists?> 2) 2 pills of TIANEPTINE 3x/day
This means that you recommend 2 pills= 2x 12.5mg (25mg) = 25 mg / 3 times a day = total of 75 mg of Tianeptine?
Why such a high dose? I dont think I could afford it ;(
Right now Im using 25 mg Tianeptine with 25 or 50mg Amisulpride and occasional Klonopin/Xanax.
> I hope I haven't bored you to death. Again, I'm not a doctor, I'm just an avid researcher obsessed with nipping this thing in the bud.
>
> Hope this helps anyone who needs it. Thanx.> Wow!. This is my well thought out, and articulate response to your hypothesis above...Dude, great post! :-)
I agree! And I repeat:) - one of the best posts about social phobia I've read.
Take care,
Brad
poster:btnd
thread:386382
URL: http://www.dr-bob.org/babble/20040915/msgs/392529.html