Posted by Dave001 on August 25, 2004, at 15:55:52
In reply to are amphet. neurotoxic?i am still unclear on this, posted by alesta on August 25, 2004, at 10:25:26
> i am still unclear as to whether this study really proves anything (concerning amphetamine neurotoxicity). it proves that at amazingly high doses, amphetamines are more toxic than ritalin. but does this prove that amphetamines are neurotoxic at normal doses, or is it impossible to really conclude from this study?
>Nobody knows the answer to that. It probably depends on a lot of factors besides just dose. Probably age is a large factor. Young animals have much more efficient natural antioxidant defense mechanisms, for example. Tolerance is also another major factor. Unless the dose is continually increased, tolerance would attenuate much of the potential neurotoxicity.
FWIW, I think that in most of the rat studies there was a "no harm" threshold somewhere around 20 mg/kg, which would be close to 3 mg/kg in a human. Then again, rats also metabolize the stuff a lot faster us, so who knows how the timing of the doses scale to humans. Again, nobody knows.
Dave
poster:Dave001
thread:380741
URL: http://www.dr-bob.org/babble/20040825/msgs/382252.html