Posted by KaraS on August 23, 2004, at 20:57:48
In reply to Re: The *Real* Truth - zeugma too » KaraS, posted by zeugma on August 23, 2004, at 18:58:31
> hi kara,
>
> i can do little other than post the results of my own experiments in reducing stim tolerance- see my post in reply to alesta further down. It puzzles me about NMDA antagonists being potentially useful- my understanding of the function of NMDA receptors, based on the textbook i have quoted extensively from, is that NMDA receptors facilitate synaptic plasticity, which would seem to be a good thing, and i had always thought that PCP, a powerful dissociative agent, was a NMDA antagonist. I can only surmise that neuroadaptation to stimulant effects is responsible for tolerance, and that by blocking this adaptation, the mind remains in an artificially 'drug-naive' state. That's my guess from poring over my dubiously accurate textbook, which does not, of course, address the problem of stimulant tolerance at all. Shame- he should do better next time. (And maybe the next edition will contain glowing accounts of the antidepressive effects of noradrenergic neurotransmission, in the wake of Cymbalta's dazzling success. One can only hope.)
>
> -z
>
> -z
>
>
Thanks. Absolutely on the Cymbalta. Are you thinking of trying it or are you just saying that for everyone else?
poster:KaraS
thread:380561
URL: http://www.dr-bob.org/babble/20040821/msgs/381534.html