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Re: How long does MAOI inhibition last with each dose? » King Vultan

Posted by don_bristol on August 3, 2004, at 7:24:38

In reply to Re: How long does MAOI inhibition last with each dose? » don_bristol, posted by King Vultan on August 2, 2004, at 20:24:36

QUOTE >> The body is producing new MAO all the time, so if, for example, you take a dose at 8 AM and one at 4 PM, the second dose has the opportunity to destroy some of the new MAO that has been created in the intervening time. Parnate's half life is so short (as is Nardil's) that very little of the first dose would be left by the time you take the second one. So by splitting the dosage, you do increase the efficiency of the MAOI. How much? I have no idea, but somebody's probably done a study on it at some point in time.

With Nardil, where the timing of the dosage does not seem directly related to insomnia as it can with Parnate, you can spread the dose evenly throughout the day, even taking a pill at bedtime to destroy some of the new MAO that has been created since the evening dose. I suppose it is extra work to split the dosage on these MAOIs, but since I have a pill container with nefedipine (for a hypertensive crisis) and ibuprofen (for regular headaches), it's not a big deal for me to throw in there the MAOI pills that I will be needing during the day.

With Parnate--as opposed to Nardil--there are a couple of other reasons to split the dosage. One is to spread the stimulatory effect out somewhat, and the other is to lessen the chance of a spontaneous hypertensive crisis, that is, a hypertensive reaction that occurs without ingesting any of the prohibited foods or drugs. For the last reason alone, I would recommend splitting the dosage, as safety should always be a high priority. << UNQUOTE

=======

Todd, thank you for a useful explanation.

I guess that we could extend the princile of splitting the dose for reasons of efficacy to taking a half-pill of Parnate several times a day to knock down the MAJORITY of the monoamine oxidase in the body.

I am guess here that like so many things if life that the amount of MAO knocked out by a full tablet of Parnate is less than double the amount of MAO knocked out by half a tablet of Parnate. (If you see what I mean.)

Sort of like the 80:20 rule of thumb where 20% of the effort produces 80% of the total results and the remaining results need a lot more effort.

Don


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