Posted by SLS on May 5, 2004, at 15:13:10
In reply to Sibutramine, posted by slinky on May 5, 2004, at 12:35:19
> Sibutramine produces its therapeutic effect by norepinephrine, serotonin and dopamine reuptake inhibition. Sibutramine and its major pharmacologically active metabolites (M1 and M2) have low affinity for serotonin (5 HT1, 5 HT1A, 5 HT1B, 5 HT2A, 5 HT2C), norepinephrine (b1 and b3, a1 and a2), dopamine (D1 and D2) benzodiazepine and glutamate receptors as well as lack monoamine oxidase inhibitory activity
>
> This med is *not* an anti depressant , it's used for obesity..
> I'm not clued up about meds but if this med affects all the neuro transmitters and doesn't cause weight gain , then it could help with depression ?
>I believe that sibutramine was originally developed as an antidepressant. It is a drug that I have my eye on. One of the things that deter me from trying it immediately is that I don't think my medical insurance will cover it off label.
As a matter of fact, one of the enantiomers of sibutramine was until recently in clinical trials for depression. The drug company shelved the project citing financial issues.
- Scott
poster:SLS
thread:343662
URL: http://www.dr-bob.org/babble/20040505/msgs/343718.html