Re: not going to cause TD over night, are they?? » linkadge

Posted by rod on April 3, 2004, at 10:32:51

In reply to not going to cause TD over night, are they??, posted by linkadge on April 3, 2004, at 9:38:59

> Correct me if I'm wrong, but I don't think that AP's are going to cause TD over night (ie short term use is a separate issue from long term use)
>
> If they do cause TD over night, I can't imagine what happend. Temporary blockade of dopamine receptors shouldn't cause any sudden morphological changes.
>
> Linkadge
You are right, as far as I know. I have read that there are multiple mechanisms responsible for TD.
One main factor apart from the supersensitized dopamine receptor theory is neuronal cell death, induced by excitotoxicity and free redicals (induced by neuroleptic drugs! shocking, eh?). I am sure neurodegeneration does not occur aver night.
Roland

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