Posted by Sad Panda on March 19, 2004, at 11:19:18
In reply to Re: Tegretol + Nardil- safe? » ace, posted by King Vultan on March 18, 2004, at 10:44:36
> > Its officially contraindicated but so are a lot of drugs which are safe with Nardil....anyone had a go at this combo??
> >
> > Ace..
>
> The contraindication appears to be because carbamazepine is a dibenzazepine derivative. IMO, this is a silly contraindication, as some of these dibenzazepine deriviatives, such as the sedating tricyclic trimipramine, appear to be relatively safe when used concomitantly with MAOIs, as they are only weak blockers of amine reuptake. Even some of the tricyclics that are powerful blockers of amine reuptake, such as desipramine, can apparently be used with MAOIs if this is done cautiously, so my opinion is that unless strange is going on with this particular drug, it looks like it is being lumped into the prohibited class somewhat unfairly.
>
> Todd
>
>NE Reuptake blockers can help prevent a hypertensive crisis as the reuptake sites is where the Tyramine enters. Clomipramine, Imipramine & Amitriptyline are the TCA's to be avoided with MAOI's because they can cause Serotonin syndrome.
Cheers,
Panda.
poster:Sad Panda
thread:325413
URL: http://www.dr-bob.org/babble/20040319/msgs/326009.html