Posted by DSCH on October 5, 2003, at 20:31:00
In reply to Re: 5HTP with Elavil still in my system?, posted by John1022 on October 5, 2003, at 20:08:24
> Thanks DSCH. I am wondering how long I should wait until I start taking it. I have been off Elavil for a week, but can steal feel that it is in my system because of the very strong personal side effects I still have from it
SLS lists a half life for amitrityline of 10-50 hours with 20 hours as the mean. The variance is due to individual differences in metabolic rate for that compound.
If you wait a period four times the half life, the serum concentration will be about 1/16 that of the peak after your last dose. Wait another half life period and it will be 1/32. One more and it will be 1/64.
OK, rule of thumb time... 1/128 seems quite dilute and you might be a slow metabolizer, so 7 periods x 50 hours/period = 350 hours (14 days and 14 hours).
How about giving it another full week just to be safe?
poster:DSCH
thread:265634
URL: http://www.dr-bob.org/babble/20031004/msgs/265786.html