Posted by Ame Sans Vie on September 15, 2003, at 18:51:22
In reply to Re: Tell me about 4-pentanolide, posted by jparsell82 on September 15, 2003, at 7:10:12
I've never noticed a tolerance to GHB, GBL, or 1,4-B even when I would take them around the clock for weeks at a time. Three grams of GHB, 1mL of GBL or 1mL of 1,4-B have always done the trick for me. But from what I understand, tolerance typically does develop if the drug is taken several times a day, every day. Xyrem, on the other hand, likely produces no tolerance in the vast majority of people because it's only used twice daily (well, nightly). Also, I was able to abruptly discontinue my heavy abuse of GHB/GBL/1,4-B without any trouble at all. Not even a craving. For those who *do* have rough withdrawals though, 4-P, GVL, or GHV are sometimes said to be sort of the "methadone" for the G-junkie. 4-P and GVL both become GHV upon ingestion, just as 1,4-B and GBL become GHB on ingestion. I now use GBL several times a week when out at the bars and such since I don't drink.
I'm eagerly awaiting reports from the scientific community on the psychotropic effects of GCL (gamma-crotonolactone; 2(5H)-Furanone), GHC (gamma-hydroxycrotonate; trans-4-hydroxycrotonoic acid [T-HCA]), and 2-B4O (2,4-butenolide), GHB analogs which are probably far superior to 4-P, GVL or GHV. Only problem is that I can't find anything that chronicles their use in humans, only rats. GCL/GHC/2-B4O can be legally ordered from chemical suppliers, but I think I'll hold off till such information is available -- better safe than sorry. Here's a bit of info on it -- I'll let you know if I find out anything exciting, lol:
"T-HCA is 16% more potent as a GHB receptor agonist than GHB itself, and most T-HCA (trans-4-hydroxy-2-butenoic acid) derivatives are more active than the corresponding GHB homologs. The 4-CH3 analog is 9%, and the 4-Ph analog is 27% more potent than GHB itself. The 4-C6H11 analog is 16% less potent than GHB, and cis-4-Hydroxy-Crotonic Acid (C-HCA) is inactive. T-HCA has also been identified as a naturally occurring substance in the CNS, which dismisses the theory of T-HCA just being a synthetic semi-rigid analog of GHB, but as a possible endogenous receptor ligand, which also competes at GHB receptors, and possibly possesses specific functions of its own."
poster:Ame Sans Vie
thread:260028
URL: http://www.dr-bob.org/babble/20030912/msgs/260394.html