Posted by Shawn. T. on August 27, 2003, at 20:57:39
In reply to DXM and seretonin syndrome link, posted by stjames on August 27, 2003, at 19:47:30
DXM exhibits two high affinity binding sites; one of these is the serotonin reuptake transporter and the other is the sigma-1 receptor. Also, it has two low affinity binding sites that have been identified as the sigma-2 receptor and the NMDA receptor. Evidence seems to suggest that DXM is a serotonin reuptake inhibitor; at very high doses, it would be expected to induce the serotonin syndrome in a similar manner to SSRI's. For this reason, high doses of DXM should not be taken with other drugs that increase synaptic serotonin levels. My reference for the serotonin transporter/DXM interaction can be found at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9105700&dopt=Abstract
Shawn
poster:Shawn. T.
thread:253550
URL: http://www.dr-bob.org/babble/20030823/msgs/254882.html