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Merida derviative stalled in FDA Phase II

Posted by DSCH on August 10, 2003, at 23:40:25

In reply to Re: Meridia » Quarterwit, posted by DSCH on August 9, 2003, at 1:36:38

http://www.sepracor.com/science/index.cfm?s=2B

"Sepracor's (R)-sibutramine metabolite is an isomer of an active metabolite of Abbott's MERIDIA®. The (R)-sibutramine metabolite has been shown in preclinical studies to be a potent norepinephrine, dopamine and serotonin reuptake inhibitor. The compound's unique triple mechanism of action may provide a broader spectrum of therapy than other currently marketed antidepressants. Physicians often prescribe various combinations of drugs to achieve similar outcomes, indicating a need for this potential therapeutic synergy.

The (R)-sibutramine metabolite development program for refractory depression is on budgetary hold due to resource constraints."


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