Posted by david_maclean on July 24, 2003, at 2:12:27
In reply to Re: Do MAOIs make normal people high?, posted by Jack Smith on July 23, 2003, at 15:35:34
David Maclean wrote:
> >
> > Is this true?
> >
> > It would certainly fit witht the idea that MAOIs have some amphetamine-like
> > metabolites.
> >
> > But is the statement that MAOI's can cause mood elevation in normal
> > individuals actually true?
> >
>JACK wrote:
>
> I remember Dr. Bodkin commenting in an article that MAOI's uniquely
> provide a more euphoric AD effect than the other classes so I would
> guess that it is not out of the question that "normal" (whatever the
> hell that means) people could get a high using them but I would
> imagine that they would have to wait at least a week for the high.
That's interesting. I have low grade chronic depression and I get a response (not really a "high" but something like that) after only a few days on Moclobemide. Of course it depends on what dose one starts at. If one is starting very cautiously then it may take a little bit longer.My impression is that this is not unusual for people who take MAOIs.
This is so fast and is so contrary to textbooks on antidepresants (which talk about a couple of weeks or more to get a beneficial response) that I do not understand it. It most definitely occurs though!
>
> As for the amphetamine metabolites, from what I understand that theory
> has been debunked.
>Do you or anyone else have any more information on this?
Thank you.
-------
>
> The link you provided does not work.
>Try http://www.medicine.uiowa.edu/pharmacology/Lectures/Lecturenotes/111/HKP-Antidepressants.pdf
The link should take you stright to a PDF document.
If that fails then Google for "proudfit maoi mood elevation" and the only two hits you get are both the authors documents which contain the statement that MAOIs can elevate mood in normals.
poster:david_maclean
thread:244562
URL: http://www.dr-bob.org/babble/20030723/msgs/244763.html