Posted by Pfinstegg on March 31, 2003, at 21:24:24
In reply to Re: rTMS - Has anyone else had this successfully? » Pfinstegg, posted by Dave1 on March 31, 2003, at 18:55:08
Hi.. I forgot to say what tianeptine is. It is considered an unusual tricyclic AD, but the molecular structure is not very close to the TCA's we are more familiar with. It does not have any anticholinergic effects, such as dry mouth, which all the other TCAs have. It also does not prolong the Q-T interval on EKG, and does not make you drowsy or feeling "flat".
The main thing it does in the brain is to INCREASE the uptake of serotonin- just the opposite of the SSRI's. The result is an increase in 5HT in parts of the hippocampus. It also increases the concentrations of norepinephrine in various parts of the brain, while decreasing them in other regions. It does not influence dopamine metabolism at all.
Most important, to me, is that it is thought to decrease the HPA axis response to stress, and to prevent damaging changes in the molecular structure of the hippocampus. HOW this occurs is not clear at all!
I hope this is relevant to your concerns.
Pfinstegg
poster:Pfinstegg
thread:213824
URL: http://www.dr-bob.org/babble/20030329/msgs/214898.html