Posted by Jonathan on October 10, 2002, at 21:09:12
In reply to Remeron and Effexor and Effexor Hell., posted by GABBI X2 on October 10, 2002, at 15:55:54
Hi Gabbi :)
You don't say whether you tried Remeron™ (mirtazapine) recently. I took it for 3 or 4 months last spring and it was disastrous for me, too: it brought me dangerously close to suicide for only the second time in my life; the first was more than 13 years earlier (though, as you said for Effexor™, I know it has helped many people).
When my pdoc told me to stop taking Remeron, he immediately started me on Manerix™ (moclobemide), which was a spectacular but short-lived success: it pulled me out of the very deep pit I was then in within only five days, but this dramatic improvement faded after a further couple of weeks; however, I still went on getting considerable benefit from Manerix for more than a year. For me, it was worth taking for the long-term effects alone, and it was the only AD I've tried that was totally without adverse effects.
You posted about a week ago that you might be starting Manerix soon.
I've been plagued by guilt for nearly a year because I never answered this post — http://www.dr-bob.org/babble/20011202/msgs/86491.html — by someone whose boyfriend had the same spectacularly positive response as I did to Manerix immediately after Remeron. I also found this similar report in the archives — http://www.dr-bob.org/babble/20010605/msgs/65966.html .
I'm pretty sure that this effect must be due to moclo-elevated NE and/or 5-HT acting on some of the many receptors which have previously been blocked and thus upregulated by Remeron (I suspect post-synaptic NE-alpha-2). I don't know if your brief exposure to Remeron would be enough to upregulate the relevant receptors (perhaps not) but it may be worth thinking about if your pdoc is still considering Manerix.
I'm glad you're out of hospital and back online: although I haven't been able for the last year to cope with the immediacy of online chat, I missed your posts on Social. I hope you're beginning to get over the worst of the Effexor withdrawal: carbamazepine (Tegretol™) — or better its newer, safer cousin oxcarbazepine (Trileptal™) — is reputed to be good for med-induced tinnitus.
Get well soon :)
Jonathan.
poster:Jonathan
thread:123098
URL: http://www.dr-bob.org/babble/20021006/msgs/123133.html