Posted by Ritch on October 6, 2002, at 22:56:15
In reply to norepinephrine uptake inhibitors (help please!) , posted by leor on October 6, 2002, at 14:34:25
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> Dear Babblers
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> Over the past month I have been taking effexor (short acting form) for the management of the ‘overfocus' symptoms of my A.D.D. (17.85mg twice a day) I also take 15 mg of Dexedrine XR once a day. My DX is bipolar II plus non-hyperactive A.D.D
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> Effexor seems to do the job nicely - but not without some nasty side effects; mild headaches and mental ‘dulling'. While under the influence, it is difficult for me to feel that my brain is fully stimulated and allways a pall of mild mental & emotional exhaustion hangs over my body.
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> I am no stranger to such problems; on or off of medications. They are with me yearround but are at their most excrutiating during the winter when I suffer from severe seassonal affective disorder.
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> Now that I am taking dexedrine for focus, and effexor to prevent over-focus it seems that it might make sense to try a norepinephrine uptake inhibitor. According to my understanding, this neurotransmitter is responsible for regulating one's stamina.
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> A MEDICATION TO DEAL WITH MY LACK OF STAMINA
> I am wondering whether anyone has suggestions about what medication to try
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> In the past my body has had difficulty tolerating wellbutrin as well as the numerous SSRI and AD's that I've tried (except in very small doses). Are there norepinephrine uptake inhibitors that deal solely with norepinephrine other than wellbutrin? If not, which of the ones available is likely to have the least effect on my serotonin level?
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> A REVERSAL EFFECT ON WELLBUTRIN
> When I was on the wellbutrin it made me very sedate to the point that I could scarcely summon up the stamina to go out of my house for about a week. After 10 days of that my p-doc took me off the med.
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> In hindsight I wonder whether what I experienced could have been the ‘reversal effect' which people sometimes experience during the initial phase of using a medicine that acts on their neurotransmitters. Has anyone experienced this themselves or come across it in the medical literature?
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> My psychiatrist has his own suggestions about what meds I should try. Though I take them seriously I always like to understand the full range of options so I can do so me good research and than make an informed decision. Thank-you.
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> Blessings,
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> Leor
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Leor, very interesting post indeed. I'm BP-II+ADHD as well. The only *very* selective NE-reuptake inhibitors around are Reboxetine (in Canada), and atomoxetine (still in clinical trials for ADHD). I'm taking Effexor (very-low-dose)+Wellbutrin (medium-dose), and Ritalin 20mg daytimes and Depakote+Neurontin+Klonopin (all low-dose) at night. I tend to get EASILY hypomanic with SSRI's (5mg of Celexa, i.e.). However, I am now taking 150mg of WB, and 20mg of Ritalin, and it is like: "Did I take anything??". If I take more of *any* SRI (which does makes it easier to switch tasks), I get out of control and start cycling more. Is it a reduced *inhibition* from the SRI that causes this by increasing impulsiveness and making thoughts TOO fluid?The "reversal" effect of Wellbutrin-I think you are definitely onto something there. I also notice some paradoxical tiredness from it. I bought a blood pressure machine (at the request of my pdoc because of polypharmacy and stimulant med), and measured my BP all day long and recorded all my meds. When the WB was supposed to be peaking-my blood pressure was dropping.. I don't understand it. I am supposed to go to 200mg WB later in the week.
poster:Ritch
thread:122549
URL: http://www.dr-bob.org/babble/20021006/msgs/122593.html