Posted by Ritch on August 26, 2002, at 9:41:58
In reply to Re: distribution » Ritch, posted by pharmrep on August 26, 2002, at 0:59:02
> > > Why do you assume this ? It is not going to happen in a pill that not ~100 % active.
> > >
> > > You need to compound to make sure you are getting active meds in your micro dose.
> >
> > I used to make a liquid out of Prozac. I made a liquid out of Celexa before, too (using a pill crusher, etc.). Quartering the tabs into chunks doesn't seem to make much of a difference. Perhaps Celexa has a long enough half-life that any uneven dosings are obscured. If the tablets do not have active medication+buffer/filler distributed evenly throughout a tablet (except on the outer shell), wouldn't that call into question whether or not each pill contains the correct total amount of medication (if it wasn't uniformly distributed)?
> >
> ***sorry guys..didnt want to create an issue...I dont how Celexa is distributed...I just know that crushing a scored 20mg to get 2.5 or less could be difficult to measure and doses might not be uniform, especially if tablets not evenly mixed throughout. (I know some manufacturers dont have uniform pills. and the active ingredient is often under the score-mark...since that is where the only "split" is thought to be made)Thanks everybody. Now I am curious about pill manufacturing technology, not necessarily creating the active medication, but how the active and inactive portions of a pill are blended together and why, how the pill is stamped/scored, imprinted. etc. I am still bewildered why the inactive fillers and active medication are not always diffused homogoneously throughout a pill. The only way I could get a consistent dose of Lexapro would be to crush the entire tablet and make a homemade liquid I guess...
Mitch
poster:Ritch
thread:109458
URL: http://www.dr-bob.org/babble/20020821/msgs/117794.html