Posted by cybercafe on July 12, 2002, at 1:13:13
In reply to Re: Some antidepressant theory, posted by Shawn. T. on July 11, 2002, at 4:35:22
Hey this is interesting stuff, thanks dude :)
http://www4.infotrieve.com/search/databases/detailsNew.asp?artID=7364595
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> This study suggests that 5-HT2 antagonists block dopamaine release in the medial prefrontal cortex:Yes fascinating, 5HT2A agonists stimulate release in the thinking centers, but decrease release in the pleasure centers... which would explain why happy people are so dumb ;)
What else is fascinating is that D2 dopamine receptors actually decrease the firing of dopaminergic neurons -- possibly because of it's decreasing the activity of adenylate cyclase? .. i dunno know if the two are connected...
>that activate 5-HT3, however. Its antagonisation can help block pain, enhance cognitive functions, and may have anxiolytic actions in some, but not all rodent and primate models of anxiety. With
.... yeah who knows... the good and bad actions of 5HT3 can all be accomplished by other means...
>regards to constipation, I've personally found that Wellbutrin and Remeron offset each other when it comes to that, although YMMV. 5-HT4
... yeah i've found gabapentin offsets antidepressants... but i also found a few vitamin supplements that help as well (help is a weak word -- complete 100% remission is more accurate)...
... any ideas on 5HT5 and 5HT6 for depression or anxiety?
poster:cybercafe
thread:111957
URL: http://www.dr-bob.org/babble/20020709/msgs/112102.html