Posted by BekkaH on July 6, 2002, at 20:20:12
In reply to Re: Balked shmalked, posted by BLPBart on July 6, 2002, at 15:51:15
I'm now having some strange side effects just showing up and I'm afraid it's the wellbutrin. I've been reading a lot lately about wb having interactions with other medications, including amphetamines. I'm thinking about just staying on the dex and see if it helps with the depression as well as the ADD.
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Hi. May I ask what strange side effects you are having on the Wellbutrin plus dexedrine combo? Wellbutrin and/or at least one of its metabolites suppresses the liver enzyme known as cytochrome P450 IID6. Dexedrine is a substrate for that enzyme (i.e., it needs the enzyme in order to be metabolized). If the enzyme is suppressed too much, then dexedrine won't be properly metabolized and could build up to dangerous levels in some people.
Some people (5-10% of Caucasians, as well as some others) have genetic polymorphisms for this enzyme, and it may not function as well as it does in those who don't have the genetic polymorphism. I know some people who do very well on that Wellbutrin + Dexedrine combination. I know others who do well on Wellbutrin + Ritalin; unfortunately, I am not one of them. I am quite certain I lack the IID6 enzyme, or else I have a "deficient" version of it. When I tried the Wellbutrin + stimulant combinations, I got quite sick, but you may not have the same problems I have. Perhaps something else is causing those strange side effects. Did you change your dosage recently?
Bekka
poster:BekkaH
thread:111452
URL: http://www.dr-bob.org/babble/20020628/msgs/111606.html