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Re: What causes med poopout the worst » OldSchool

Posted by Bob on March 28, 2002, at 13:05:15

In reply to Re: What causes med poopout the worst, posted by OldSchool on March 28, 2002, at 10:59:31


> Let me explain it very very specifically Bob. Say you are on Remeron for major depression. Youve been on 15 mg Remeron for three weeks and your Pdoc bumps you up to 30 mg. After a week at 30 mg you find your really sedated and getting really fat. You are like "fuck this" so you drop back down to 15 mg on your own, indecisive as many severe depressives tend to me. You remain at 15 mg for a week, find your getting more depressed and realized you made a mistake. (more decision making problems common to severe depression and inability to think clearly) So you bump it back up to 30 mg, only to find that low and behold it doesnt activate good like it did the first time. Do this a third time and your meds will be like water...fadeout to the max.
>
> This is my point. Going on and off the same antidepressant within a short time period "does things" and in my opinion is one of the things that causes med poopout the worst of anything.
>
> thats why I tell depression "newbies" the best thing they can do for themselves when going on ADs is to play it slow and steady. Once on an AD, STAY on the AD and dont play games with your meds. Dont change the dosage yourself, dont be wishy washy and decide one day you dont need the AD, only to find out two weeks later your depressed as dirt again and really do need the med. Only when returning to the med, you find out its losts its punch.
>
> See what I mean...this combination of denial so many have (stopping their meds) along with hating side effects which leads to stopping meds, then when reality hits later, many find that their meds no longer work good anymore.
>
> this is a big reason for antidepressant poopout in my personal opinion.
>
> Old School

I guess the main point I missed was coming on and off the *same* drug. I still have a problem with it though, because the scenario you described above with the Remeron is symptomatic of human nature. People aren't doing these things for shits and giggles, but because it's human nature - they can't help it. In fact, I often read stories about how mere compliance with taking a pill once a day is not very well adhered to for a majority of the population. I personally cannot afford that luxury any longer, as that would blow away what little stability I have. If I miss any doses, I feel it.

Possibly the "depot injections" you have suggested would be viable alternative, but I would think very few people would be up to opting for an injection over a pill.

Do you think ECT would renew a person's response to a med they had "worn out" by going on and off?

 

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