Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: AD meds and BP response » OldSchool

Posted by JohnX2 on March 26, 2002, at 13:29:52

In reply to Re: AD meds and BP response, posted by OldSchool on March 26, 2002, at 10:44:56

> Here is my own prediction concerning my upcoming ECT. How much do you wanna bet that my blood pressure goes down a lot after ECT because I will be more relaxed? I think ECT will help my BP.

From what I was reading about high blood pressure, it is often associated with a excess glucorcorticoid production state (do a web search). This may linked to a hyperacitive HPA (hypothalamaus-pituitary-adrenal-gland) axis. This is consistent with classic markers of depression. Hyperadrenal gland can cause dysfunctional noradrenargic system in general. You can acutally get this tested. The glucocorticoid receptors in the hypothalamus etc are desensitized to cortisol feedback and release too much of a substance ACTH. These causes too much secretion of cortisol (and high blood pressure) and continued depression. It may also make you agitated. CRF antagonists may fix this. Most ADs over time are thought to correct a malfunctioning feedback loop in the HPA axis. I would hope this would have an effect of fixing a hypercorisolemia state and possibly helping your bp. BTW, some people believe that NMDA antagonists may act as atypical CRF antagonists.

I believe some of the dopamine agonists reduce noradrenergic output by stimulating presyaptic d2/d3 recptors at the lower doses. Pramipexole I seem to recall has hypotensive effects at low doses (at is selective for presynaptice autoreceptors. At the higher doses, they are less selective and stimulate the post synaptic d2 receptors If I recall (may lead to the psychosis). I believe Bromocriptine depletes noradrenaline release at the lower doses.

This is all my quick-n-dirty conjecture, as always.

http://www.acnp.org/g4/GN401000049/Default.htm
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2067174&dopt=Abstract
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2161850&dopt=Abstract

Have you tried a mild atypical bp medicine like an alpha-2 agonist (clonidine, tenex)? This reduces norepinephrine release. Maybe a good handshake with an NRI AD. (OK a SWAG).

Regards
John

Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in
This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:JohnX2 thread:99962
URL: http://www.dr-bob.org/babble/20020322/msgs/100313.html