Posted by pellmell on September 21, 2001, at 11:18:18
In reply to Re: Experiences w/ switching from SSRI to tricyclic? » Jane D, posted by Cam W. on September 20, 2001, at 17:38:23
Thanks, Cam...this could explain why I even go through withdrawal coming off of Prozac. The symptoms I experience are pretty minor, but definitely there.
Could this also explain why I needed 200mg of Zoloft (+Li) to feel any effect? And why Effexor doesn't seem to be doing much even at 225mg?
Oh, and I've come up with another (maybe farfetched) theory: this could also explain my sensitivity to Wellbutrin. Perhaps my body creates a lot of an active activating bupropion metabolite very quickly, leading to a quick case of the jitters. 150mg Wellbutrin SR/day seems to be plenty for me.
Do you know off hand if Celexa is metabolized through this same pathway? If you don't, I'll look it up on rxlist.com sometime. I'm asking 'cause I'm considering asking my pdoc if I can give it a try if things don't work out on my current Effexor/Wellbutrin mix.
Thanks for putting up with my recent ramblings,
-pm
> Jane - I have seen withdrawl symptoms with Zoloft™ (sertraline) and Luvox™ (fluvoxamine), as well. It seems that it happens to people who metabolize these drugs more quickly. These people possibly have multiple copies of the cytochrome-P450-2D6 gene. I believe that this occurs in about 10% of people of European descent (I could be wrong). This would explain why some people have extreme difficulty withdrawing from Effexor, as well.
>
> - Cam
poster:pellmell
thread:79138
URL: http://www.dr-bob.org/babble/20010917/msgs/79220.html