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Re: Drug-induced Sexual Dysfunction Augmentation » SalArmy4me

Posted by nike on June 2, 2001, at 13:54:33

In reply to Re: Drug-induced Sexual Dysfunction Augmentation » Thrud, posted by SalArmy4me on May 30, 2001, at 4:27:58

> From . Landen, Mikael MD et al. Effect of Buspirone on Sexual Dysfunction in Depressed Patients Treated With Selective Serotonin Reuptake Inhibitors. Journal of Clinical Psychopharmacology. 19(3):268-271, June 1999:
>
> "Basically, we're talking about buspirone fighting sexual dysfunction in SSRI's. The mechanism of action in this is not obvious. Selective alpha2 receptor antagonists facilitate sexual behavior in animals; moreover, the alpha2 receptor antagonists yohimbine and mianserin have been reported to reduce SSRI-induced sexual dysfunction in man. Thus, the assumption that the effect of buspirone on sexual function is a result of the alpha2 receptor antagonism exerted by the buspirone metabolite 1-(2-pyrimidyl) piperazine dihydrochloride is not far-fetched. However, given the profound influence of 5-HT1A receptors on sexual activity in rodents, the possibility that the partial agonism exerted by buspirone vis-a-vis this receptor subtype is also of importance in this context and cannot be excluded.
>
> Menkes, D. B.. Buspirone Augmentation of Sertraline. British Journal of Psychiatry. 166(6):823-824, June 1995.
> This case-study claims the use of 60-90 mg of buspirone is needed for adequate treatment of depression.

>I´ve tried buspirone added to Zoloft to decrease sexual dysfunction. It had no effect at all. What would be the best to try next? Which SSRI causes least(or none!)sexual dysfunction in woman?
/nike


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