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Re: Report of success: Selegiline: alernate MAOI

Posted by JohnX on March 14, 2001, at 2:09:48

In reply to Report of success: Selegiline: alernate MAOI, posted by SalArmy4me on March 13, 2001, at 16:03:37

> I have been on Selegiline for only two days at a dose of 60 mg in three divided doses. (I do not have Parkinsons' disease, but rather Treatment-Resistant Depression. I have taken every other antidepressant known to mankind). So far, I have noticed a moderate antidepressant effect after one hour of ingesting it, which I could never get from a placebo. And that is why I'm writing this, to alert others.
>
> Selegiline should be known as the "alternative" MAOI, in that it has less of the side-effects of phenelzine or tranylcypromine. The main side-effect that I have with it is a powerful stimulating effect similar to one caused by buproprion. I have been taking 10 mg oxazepam along with selegiline in order to counter the anxiety produced by selegiline.
>
> Notes:
> --I don't think that selegiline has an antidepressant effect under doses of 40 mg per day.
> --I don't know if selegiline has any sexual side-effects yet.
> --100 of the Generic 5 mg capsules (you need 240 capsules for a months antidepressant supply) costs US $240 at Sav-On Drug Stores. That is expensive. However, medical insurance covers it.
> --You have to drop almost every other antidepressant in order to take the MAOI selegiline, although there is only one reported case in history of Serotonin Syndrome (that is fact).
> --You have to follow the MAOI diet (I won't, though. I didn't on phenelzine or tranylcypromine and didn't have a hypertensive crisis).

All,

Selegiline is on my list of things to try along
with Mirapex and some other more dopamnergic acting meds.

A question about Selegeline:

People seem to be getting various responses at various doses, any thoughts?

Is the cutoff point for the MAOI diet restriction around 15 mg/day?

Also, I remember threads on the patch version, which didn't have the dietary restrictions. Is this version available for importation from overseas?

I did well on Adderall ~20mg/day to relieve anhedonia, but am finding it *much* harder to get a script for in the state I just moved too given I'm not ADD. Selegiline is not as restrictive, and the funny thing is that it is an MAO-B inhibitor, but you may not know that it also breaks down into meth-amphetamine.

Based on my Adderal response at 20mg/day, anyone want to venture a guess as to what dose I might get any response on Selegiline? (I'm also looking into atypical anti-psychotics such as Zyprexa and Ziprasidone, the 5ht-2 antagonism is cross-my- fingers good for the anhedonia I experience).

-John


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poster:JohnX thread:56408
URL: http://www.dr-bob.org/babble/20010310/msgs/56461.html