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Re: Neurontin as a mood stabilizer » Chaston

Posted by SalArmy4me on March 12, 2001, at 12:29:26

In reply to Neurontin as a mood stabilizer, posted by Chaston on March 12, 2001, at 10:47:29

Neurontin has an elimination half life in the body of 6-8 hours, so I doubt you would get any benefit from taking it once at bedtime.

Here are the benefits of Neurontin:
--It less drowsiness, sexual side-effects,
--it does not have anticholinergic side-effects
--it comes in many different dosages
--it has gained the respect of psychiatrists in less than a decade of FDA approval

Here are the studies that prove Neurontin's efficacy:
1: Jefferson JW.
Benzodiazepines and anticonvulsants for social
phobia (social anxiety disorder).
J Clin Psychiatry. 2001;62 Suppl 1:50-3.
PMID: 11206035

2: Janowsky DS.
New Treatments of Bipolar Disorder.
Curr Psychiatry Rep. 1999 Dec;1(2):111-113.
PMID: 11122912

3: Keck PE, Mendlwicz J, Calabrese JR, Fawcett J,
Suppes T, Vestergaard PA, Carbonell C.
A review of randomized, controlled clinical
trials in acute mania.
J Affect Disord. 2000 Sep;59 Suppl 1:S31-S37.
PMID: 11121825

4: [No authors listed]
Valproate and other anticonvulsants for psychiatric disorders.
Med Lett Drugs Ther. 2000 Dec 11;42(1094):114-5.
PMID: 11114842

5: Vieta E, Martinez-Aran A, Nieto E, Colom F,
Reinares M, Benabarre A, Gasto C.
Adjunctive gabapentin treatment of bipolar disorder.
Eur Psychiatry. 2000 Nov;15(7):433-7.
PMID: 11112936

6: Frye MA, Ketter TA, Kimbrell TA, Dunn RT, Speer AM,
Osuch EA, Luckenbaugh DA, Cora-Ocatelli G, Leverich GS, Post RM.
A placebo-controlled study of lamotrigine and
gabapentin monotherapy in refractory mood disorders
J Clin Psychopharmacol. 2000 Dec;20(6):607-14.
PMID: 11106131
8: McElroy SL, Keck PE.
Pharmacologic agents for the treatment of acute
bipolar mania
Biol Psychiatry. 2000 Sep 15;48(6):539-57.
[Record as supplied by publisher]
PMID: 11018226

9: Bennett J, Goldman WT, Suppes T.
Gabapentin for treatment of bipolar and schizo-
affective disorders.
J Clin Psychopharmacol. 1997 Apr;17(2):141-2.
PMID: 10950494

10: Pande AC, Pollack MH, Crockatt J, Greiner M,
Chouinard G, Lydiard RB, Taylor CB, Dager SR, Shiovitz T.
Placebo-controlled study of gabapentin treatment
of panic disorder.
J Clin Psychopharmacol. 2000 Aug;20(4):467-71.
PMID: 10917408

12: Ghaemi SN, Gaughan S.
Novel anticonvulsants: a new generation of mood stabilizers?
Harv Rev Psychiatry. 2000 May-Jun;8(1):1-7. Review.
PMID: 10824292

15: Brannon N, Labbate L, Huber M.
Gabapentin treatment for posttraumatic stress disorder.
Can J Psychiatry. 2000 Feb;45(1):84.
PMID: 10696495

16: Dallocchio C, Buffa C, Mazzarello P.
Combination of donepezil and gabapentin for behavioral
disorders in Alzheimer's disease.
J Clin Psychiatry. 2000 Jan;61(1):64.
PMID: 10695652

17: Herrmann N, Lanctot K, Myszak M.
Effectiveness of gabapentin for the treatment of
behavioral disorders in dementia.
J Clin Psychopharmacol. 2000 Feb;20(1):90-3.
PMID: 10653214

19: Schaffer CB, Schaffer LC.
Open maintenance treatment of bipolar disorder spectrum
patients who responded to gabapentin augmentation in
the acute phase of treatment.
J Affect Disord. 1999 Oct;55(2-3):237-40.
PMID: 10628894

20: Maurer I, Volz HP, Sauer H.
Gabapentin leads to remission of somatoform pain
disorder with major depression.
Pharmacopsychiatry. 1999 Nov;32(6):255-7.
PMID: 10599936

21: Sokolski KN, Green C, Maris DE, DeMet EM.
Gabapentin as an adjunct to standard mood stabilizers
in outpatients with mixed bipolar symptomatology.
Ann Clin Psychiatry. 1999 Dec;11(4):217-22.
PMID: 10596736

22: Brown ES, Hong SC.
Antidepressant-induced bruxism successfully treated
with gabapentin.
J Am Dent Assoc. 1999 Oct;130(10):1467-9.
PMID: 10570590

23: Botts SR, Raskind J.
Gabapentin and lamotrigine in bipolar disorder.
Am J Health Syst Pharm. 1999 Oct 1;56(19):1939-44. Review.
PMID: 10554911

24: Magnus L.
Nonepileptic uses of gabapentin.
Epilepsia. 1999;40 Suppl 6:S66-72; discussion S73-4. Review.
PMID: 10530686

25: Connor KM, Davidson JR, Sutherland S, Weisler R.
Social phobia: issues in assessment and management.
Epilepsia. 1999;40 Suppl 6:S60-5; discussion S73-4. Review.
PMID: 10530685

26: Young LT, Robb JC, Hasey GM, MacQueen GM,
Patelis Siotis I, Marriott M, Joffe RT. <
Gabapentin as an adjunctive treatment in bipolar disorder.
J Affect Disord. 1999 Sep;55(1):73-7.
PMID: 10512610

27: Post RM.
Comparative pharmacology of bipolar disorder and schizophrenia.
Schizophr Res. 1999 Sep 29;39(2):153-8; discussion 163. Review.
PMID: 10507527

28: Perugi G, Toni C, Ruffolo G, Sartini S, Simonini E, Akiskal H.
Clinical experience using adjunctive gabapentin in treatment-
resistant bipolar mixed states.
Pharmacopsychiatry. 1999 Jul;32(4):136-41. Review.
PMID: 10505483

29: Hardoy MC, Hardoy MJ, Carta MG, Cabras PL.
Gabapentin as a promising treatment for antipsychotic-induced
movement disorders in schizoaffective and bipolar patients.
J Affect Disord. 1999 Aug;54(3):315-7.
PMID: 10467977

30: Harden CL, Lazar LM, Pick LH, Nikolov B, Goldstein MA,
Carson D, Ravdin LD, Kocsis JH, Labar DR.
A beneficial effect on mood in partial epilepsy patients
treated with gabapentin.
Epilepsia. 1999 Aug;40(8):1129-34.
PMID: 10448827

31: Pande AC, Davidson JR, Jefferson JW, Janney CA,
Katzelnick DJ, Weisler RH, Greist JH, Sutherland SM.
Treatment of social phobia with gabapentin: a placebo-
controlled study.
J Clin Psychopharmacol. 1999 Aug;19(4):341-8.
PMID: 10440462

32: Grunze H, Erfurth A, Amann B, Normann C, Walden J.
[Gabapentin in the treatment of mania].
Fortschr Neurol Psychiatr. 1999 Jun;67(6):256-60. German.
PMID: 10399045

33: Ketter TA, Frye MA, Cora-Locatelli G, Kimbrell TA, Post RM.
Metabolism and excretion of mood stabilizers and new anticonvulsants.
Cell Mol Neurobiol. 1999 Aug;19(4):511-32. Review.
PMID: 10379423

34: Dodrill CB, Arnett JL, Hayes AG, Garofalo EA, Greeley CA,
Greiner MJ, Pierce MW.
Cognitive abilities and adjustment with gabapentin:
results of a multisite study.
Epilepsy Res. 1999 Jun;35(2):109-21.
PMID: 10372564

35: Lovell RW.
Mood stabilizer combinations for bipolar disorder.
Am J Psychiatry. 1999 Jun;156(6):980-1. No abstract available.
PMID: 10360163

37: Letterman L, Markowitz JS.
Gabapentin: a review of published experience in the
treatment of bipolar disorder and other psychiatric conditions.
Pharmacotherapy. 1999 May;19(5):565-72. Review.
PMID: 10331819

38: Cabras PL, Hardoy MJ, Hardoy MC, Carta MG.
Clinical experience with gabapentin in patients with bipolar
or schizoaffective disorder: results of an open-label study.
J Clin Psychiatry. 1999 Apr;60(4):245-8.
PMID: 10221286

40: Hatzimanolis J, Lykouras L, Oulis P, Christodoulou GN.
Gabapentin as monotherapy in the treatment of acute mania.
Eur Neuropsychopharmacol. 1999 Mar;9(3):257-8.
PMID: 10208297

41: Walden J, Normann C, Langosch J, Grunze H.
[Predictors of response to phase prophylactics (mood stabilizers)
in bipolar affective disorders].
Fortschr Neurol Psychiatr. 1999 Feb;67(2):75-80. Review. German.
PMID: 10093780

45: Erfurth A, Kammerer C, Grunze H, Normann C, Walden J.
An open label study of gabapentin in the treatment of acute mania.
J Psychiatr Res. 1998 Sep-Oct;32(5):261-4.
PMID: 9789203

46: Dopheide JA, Wincor MZ.
Gabapentin and lamotrigine in the treatment of bipolar disorder.
J Am Pharm Assoc (Wash). 1998 Sep-Oct;38(5):632-4.
PMID: 9782699

47: Ferrier IN.
Lamotrigine and gabapentin. Alternative in the treatment of bipolar disorder.
Neuropsychobiology. 1998 Oct;38(3):192-7. Review.
PMID: 9778608

48: Post RM, Denicoff KD, Frye MA, Dunn RT, Leverich GS, Osuch E, Speer A.
A history of the use of anticonvulsants as mood stabilizers
in the last two decades of the 20th century.
Neuropsychobiology. 1998 Oct;38(3):152-66.
PMID: 9778604

49: Ghaemi SN, Katzow JJ, Desai SP, Goodwin FK.
Gabapentin treatment of mood disorders: a preliminary study.
J Clin Psychiatry. 1998 Aug;59(8):426-9.
PMID: 9721823

50: Dunn RT, Frye MS, Kimbrell TA, Denicoff KD, Leverich GS, Post RM.
The efficacy and use of anticonvulsants in mood disorders.
Clin Neuropharmacol. 1998 Jul-Aug;21(4):215-35. Review.
PMID: 9704164

51: Blinder BJ, Bhat S, Sanathara VA.
Advances in mood stabilizing medications.
West J Med. 1998 Jul;169(1):39-40.
PMID: 9682629

52: Keck PE, McElroy SL, Strakowski SM.
Anticonvulsants and antipsychotics in the treatment of bipolar disorder.
J Clin Psychiatry. 1998;59 Suppl 6:74-81; discussion 82. Review.
PMID: 9674940

53: Pollack MH, Matthews J, Scott EL. <
Gabapentin as a potential treatment for anxiety disorders.
Am J Psychiatry. 1998 Jul;155(7):992-3.
PMID: 9659873

54: Post RM, Frye MA, Denicoff KD, Leverich GS, Kimbrell TA, Dunn RT.
Beyond lithium in the treatment of bipolar illness.
Neuropsychopharmacology. 1998 Sep;19(3):206-19. Review.
PMID: 9653709

55: Soutullo CA, Casuto LS, Keck PE.
Gabapentin in the treatment of adolescent mania: a case report.
J Child Adolesc Psychopharmacol. 1998;8(1):81-5.
PMID: 9639083

56: Knoll J, Stegman K, Suppes T.
Clinical experience using gabapentin adjunctively in
patients with a history of mania or hypomania.
J Affect Disord. 1998 Jun;49(3):229-33.
PMID: 9629953

57: Sheldon LJ, Ancill RJ, Holliday SG.
Gabapentin in geriatric psychiatry patients.
Can J Psychiatry. 1998 May;43(4):422-3.
PMID: 9598285

58: Chouinard G, Beauclair L, Belanger MC.
Gabapentin: long-term antianxiety and hypnotic effects in
psychiatric patients with comorbid anxiety-related disorders.
Can J Psychiatry. 1998 Apr;43(3):305.
PMID: 9561320
60: Freeman MP, Stoll AL.
Mood stabilizer combinations: a review of safety and efficacy.
Am J Psychiatry. 1998 Jan;155(1):12-21. Review.
PMID: 9433333

61: Watson WP, Robinson E, Little HJ. <
The novel anticonvulsant, gabapentin, protects against both
convulsant and anxiogenic aspects of the ethanol withdrawal syndrome.
Neuropharmacology. 1997 Oct;36(10):1369-75.
PMID: 9423924

62: Young LT, Robb JC, Patelis-Siotis I, MacDonald C, Joffe RT.
Acute treatment of bipolar depression with gabapentin.
Biol Psychiatry. 1997 Nov 1;42(9):851-3.
PMID: 9347136

64: McElroy SL, Soutullo CA, Keck PE, Kmetz GF.
A pilot trial of adjunctive gabapentin in the treatment
of bipolar disorder.
Ann Clin Psychiatry. 1997 Jun;9(2):99-103.
PMID: 9242896

65: Ryback RS, Brodsky L, Munasifi F.
Gabapentin in bipolar disorder.
J Neuropsychiatry Clin Neurosci. 1997 Spring;9(2):301.
PMID: 9144113

66: Schaffer CB, Schaffer LC.
Gabapentin in the treatment of bipolar disorder.
Am J Psychiatry. 1997 Feb;154(2):291-2.
PMID: 9016291

67: Stanton SP, Keck PE, McElroy SL.
Treatment of acute mania with gabapentin.
Am J Psychiatry. 1997 Feb;154(2):287.
PMID: 9016284

68: Singh L, Field MJ, Ferris P, Hunter JC, Oles RJ, Williams RG, Woodruff GN.
The antiepileptic agent gabapentin (Neurontin) possesses
anxiolytic-like and antinociceptive actions that are reversed by D-serine.
Psychopharmacology (Berl). 1996 Sep;127(1):1-9.
PMID: 8880937
69: Dimond KR, Pande AC, Lamoreaux L, Pierce MW.
Effect of gabapentin (Neurontin) [corrected] on mood and
well-being in patients with epilepsy.
Prog Neuropsychopharmacol Biol Psychiatry. 1996 Apr;20(3):407-17.
PMID: 8771597

71: Walden J, Hesslinger B.
[Value of old and new anticonvulsants in treatment of psychiatric diseases].
Fortschr Neurol Psychiatr. 1995 Aug;63(8):320-35. Review. German.
PMID: 7557815

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