Posted by JohnX on February 15, 2001, at 4:09:48
In reply to Re: Re; psychopharmacology of lamictal, posted by SLS on February 12, 2001, at 18:47:10
> > Any idea why Lamictal would show more of an
> > antidepressant effect than say Depakote, which
> > also blocks sodium channels and reduces the
> > excitation of glutamate? Of course Depakote
> > also does a job interfering with calcium
> > channels and enhancing gaba.
> >
> > -John
>
>
> My guess is that lamotrigine may possess a pro-dopaminergic property that is independent of its reduction of extracellular glutamate concentrations. It seems to help prevent MPTP-induced dopamine depletions in laboratory animals. It also has a restorative effect upon MPTP-treated mice when combined with l-dopa. It shares this property with selegiline (l-deprenyl). In addition, there are anecdotal reports that lamotrigine has produced tics (abnormal movements) and Tourette's Syndrome in a manner similar to methylphenidate or amphetamine.
>
>
> - ScottScott,
I have developed chronic muscle tension in my
jaw and head shortly after taking SSRIs. I also
have random twitches too. I have
found that Adderall,Klonopin,and,Lamotrigine
all relieve the symptoms (taken 1 at a time).
I've read that both hyper and hypo dopaminergic
states can cause muscle spasms. Any thoughts?-John
poster:JohnX
thread:53739
URL: http://www.dr-bob.org/babble/20010212/msgs/54046.html