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Re: What do you make of this lot ?

Posted by Devlin on December 13, 2000, at 20:13:00

In reply to Re: What do you make of this lot ?, posted by stjames on December 13, 2000, at 17:04:06

> This is all well and good, the cardioprotective
> effects of EFA's are well known. It seems you are
> saying all mental illness comes from lack of EFA's. Prove that.
>


OK I can't but research is just too promising to ignore. The EPA capsules are cheap and cause indigestion at most. Relief comes 1-4 weeks.

The fatty acids in fish oils are promising to unlock understanding of brain development. Depressive, Schizophric and BP conditions are manifestations of Neural structure disorder. Not all mental illness has the same cause but it appears they may be related in ways we had not considered. Also when we try to adjust Neurotransmission with AD's the brain is strained yet again (and its already having development problems as it is.) The majority of patients from the complete disorder spectrum respond to fatty acid treatments. I reckon this is the healthy way to go. Here is a case of one patient whose brain restructured itself after EPA treatment.

PATIENT WHO RESPONDED TO EPA

In the poster session Drs. Alex Richardson and Basant Puri presented long-term follow-up findings on their patient with schizophrenia whose case was first reported in Archives of General Psychiatry (2-4). This young man had been seriously ill and unmedicated for 12 years following a violent adverse reaction to an antipsychotic drug. Kirunal alone caused a near complete resolution of his symptoms. This patient has now been followed up for three and a half years and continues to be well while taking EPA alone without any other antipsychotic agent (3,4). His blood fatty acids have returned to normal. Most importantly his brain magnetic resonance imaging scans also indicate a restructuring in a favourable direction. Some patients with schizophrenia show slowly progressive enlargement of the ventricles, the fluid-filled spaces in the middle of the brain. This probably means that brain tissue is being slowly lost. Prior to being treated with EPA, brain scans showed a progressive ventricular expansion in this patient, whereas on Kirunal the ventricular expansion was reversed.


This published this month


Human requirement for N-3 polyunsaturated fatty acids.

Simopoulos AP

The Center for Genetics Nutrition and Health, Washington, DC 20009, USA. cgnh@bellatlantic.net

[Medline record in process]

The diet of our ancestors was less dense in calories, being higher in fiber, rich in fruits, vegetables, lean meat, and fish. As a result, the diet was lower in total fat and saturated fat, but contained equal amounts of n-6 and n-3 essential fatty acids. Linoleic acid (LA) is the major n-6 fatty acid, and alpha-linolenic acid (ALA) is the major n-3 fatty acid. In the body, LA is metabolized to arachidonic acid (AA), and ALA is metabolized to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The ratio of n-6 to n-3 essential fatty acids was 1 to 2:1 with higher levels of the longer-chain polyunsaturated fatty acids (PUFA), such as EPA, DHA, and AA, than today's diet. Today this ratio is about 10 to 1:20 to 25 to 1, indicating that Western diets are deficient in n-3 fatty acids compared with the diet on which humans evolved and their genetic patterns were established. The n-3 and n-6 EPA are not interconvertible in the human body and are important components of practically all cell membranes. The N-6 and n-3 fatty acids influence eicosanoid metabolism, gene expression, and intercellular cell-to-cell communication. The PUFA composition of cell membranes is, to a great extent, dependent on dietary intake. Therefore, appropriate amounts of dietary n-6 and n-3 fatty acids need to be considered in making dietary recommendations. These two classes of PUFA should be distinguished because they are metabolically and functionally distinct and have opposing physiological functions; their balance is important for homeostasis and normal development. Studies with nonhuman primates and human newborns indicate that DHA is essential for the normal functional development of the retina and brain, particularly in premature infants. A balanced n-6/n-3 ratio in the diet is essential for normal growth and development and should lead to decreases in cardiovascular disease and other chronic diseases and improve mental health. Although a recommended dietary allowance for essential fatty acids does not exist, an adequate intake (AI) has been estimated for n-6 and n-3 essential fatty acids by an international scientific working group. For Western societies, it will be necessary to decrease the intake of n-6 fatty acids and increase the intake of n-3 fatty acids. The food industry is already taking steps to return n-3 essential fatty acids to the food supply by enriching various foods with n-3 fatty acids. To obtain the recommended AI, it will be necessary to consider the issues involved in enriching the food supply with n-3 PUFA in terms of dosage, safety, and sources of n-3 fatty acids.


I hate being right so A contradicting paper.


Short-term supplementation of low-dose gamma -linolenic acid (GLA), alpha -linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent.

Fokkema MR, Brouwer DA, Hasperhoven MB, Martini IA, Muskiet FA

Department of Pathology and Laboratory Medicine, Groningen University Hospital, Groningen, The Netherlands


Its amazing that these Biology headers from last two years tracking fatty acids and Neurodevelopment did'nt cross reference with the Psychiatric research. I thought the internet was made for Scientists. Oh well........

The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development
Andreas Kurtz, Andreas Zimmer, Frank Schnütgen, Gerold Brüning, Friedrich Spener and Thomas Müller

Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex
E. S. Anton, M. A. Marchionni, K-F. Lee and P. Rakic
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510-8001, USA


Differentiating neurons activate transcription of the brain lipid-binding protein gene in radial glia through a novel regulatory element
Lei Feng and Nathaniel Heintz


Effects of GGF/neuregulins on neuronal survival and neurite outgrowth correlate with erbB2/neu expression in developing rat retina
Olivia Bermingham-McDonogh, Kathryn L. McCabe and Thomas A. Reh


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poster:Devlin thread:50485
URL: http://www.dr-bob.org/babble/20001130/msgs/50535.html