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Re: A little Zoloft info

Posted by Cam W. on March 11, 2000, at 22:19:01

In reply to Re: zoloft dosage tricks to help nausea, posted by JohnL on March 10, 2000, at 4:47:15

Jan - Zoloft should be taken with meals and not only for the nausea (but it helps for that as well). When you eat your blood circulation increases and thus, blood circulation through the liver increases. This increased circulation allows more of the Zoloft to travel through the liver unmetabolized. When the Zoloft is absorbed (or any drug for that matter) it first goes through the liver and then to the rest of the body (incl. the brain). This is called the 'first pass effect'. First pass effect is one way the body helps keep ingested toxins from reaching the brain. More unmetabolized Zoloft presumably leads to more effect in the brain. I would think that this would hold for any drug (unless food deactivates or binds to it - eg. tetracycline and divalent cations). I have only heard this recommendation for Zoloft. I believe it can from a company (Pfizer) shill. It may have been said to take our mind off the fact that Zoloft can cause a lot of stomach irritation. Maybe someone else has seen this in the literature, as it was a few years ago that I heard it and haven't heard it again. - Cam W.


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poster:Cam W. thread:26390
URL: http://www.dr-bob.org/babble/20000302/msgs/26734.html