Posted by Mike on September 17, 1999, at 13:31:37
Hi,
Anyone have experience in successfully treating social phobia with SJW either LI-160 (Lictwer Pharma AG), brand name "Kira" in the U.S. or WS-5572 (Boehringer-Ingleheim), brand name "Movana" in the U.S.? LI-160 is the patented compound of SJW used in the majority of clinical research which I was able to find in my search of PubMed. It's standardized to 0.3% hypericin. It's also the compound currently in clinical trials sponsored by the NIMH and overseen by J. Davidson.
However, some recent research suggests the most efficacious component of SJW may be hyperforin, as opposed to hypericin (see PubMed). WS-5572 is a patented extraction standardized to a minimum of 3.0% hyperforin and 0.3% hypericin. Apparently, Boehringer has developed a special process for extracting the hyperforin and then enabling it to have substantial shelf-life.
Also, any information on dosage would help, if you have had a successful experiences. I see through PubMed that the majority of research has been with LI-160 at 900 mg/day. This may be sub-therapeutic. I've heard of people taking 1800 mg/day to 2400 mg/day. Concerns of photoxicity even at that level may not be completely significant. I understand that most issues of photoxicity have involved compounds other than LI-160 or WS-5572, or have come from livestock grazing on the raw herb, H. Perforatum.
poster:Mike
thread:11708
URL: http://www.dr-bob.org/babble/19990914/msgs/11708.html