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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 19 to 43 of 43. Go back in thread:
Posted by Shawn. T. on July 6, 2005, at 15:31:28
In reply to Substance P's: poorly-tolerated HIV drugs?, posted by utopizen on July 6, 2005, at 14:43:40
Saredutant does not block the high affinity receptor for substance P.
Shawn
Posted by cncgordon on September 4, 2005, at 1:30:30
In reply to Re: Substance P's: poorly-tolerated HIV drugs?, posted by Shawn. T. on July 6, 2005, at 15:31:28
I am taking part in the Saredutant study. I have so many questions and the only information you can find is how a rat reacts to having their neck rubbed or when they are exposed to a cat. I feel like such a lab rat it isn't funny. Will let you know how things go.
Posted by cncgordon on September 4, 2005, at 1:36:41
I am in the phase3 study of saredutant. I am hoping to find others that are participating in the study as well. I figure it will be like finding a needle in a hay stack but worth a try.
If anyone has any other information besides how mice react to having thier necks scatched or how a rat reacts to being put face to face with a cat then please feel free to e-mail me.
Posted by Phillipa on September 4, 2005, at 19:03:40
In reply to saredutant study, posted by cncgordon on September 4, 2005, at 1:36:41
What in the world is it? Fondly, Phillipa
Posted by cncgordon on September 5, 2005, at 9:16:05
In reply to Re: saredutant study, posted by Phillipa on September 4, 2005, at 19:03:40
It is a new drug to treat depression.
Posted by Phillipa on September 5, 2005, at 16:09:40
In reply to Re: saredutant study, posted by cncgordon on September 5, 2005, at 9:16:05
Thanks so much. What country is it in? Fondly, Phillipa
Posted by cncgordon on September 6, 2005, at 9:21:33
In reply to Re: saredutant study » cncgordon, posted by Phillipa on September 5, 2005, at 16:09:40
It's a world wide study. I believe there are only 250 people in this phase of the study but I could be wrong.
Posted by ravenstorm on September 8, 2005, at 13:48:50
In reply to Saredutant study, posted by cncgordon on September 4, 2005, at 1:30:30
Where are you taking part in this study? Have you had any side effects, or do you think you've been given the placebo. Any information would be great!
Posted by ravenstorm on September 8, 2005, at 14:12:32
In reply to Re: saredutant study, posted by cncgordon on September 6, 2005, at 9:21:33
Where are you participating in this study? Have you started taking the drug or placebo yet? Can you tell which one you are getting by side effects or benefits etc?
How did you find out about the study. I may be interested in this as well.
Have they given you any further information about the drug, like when they think they will be done with phase III, if the drug has any withdrawal effects etc etc?
Thanks, K
Posted by cncgordon on September 9, 2005, at 0:59:26
In reply to Re: saredutant study, posted by ravenstorm on September 8, 2005, at 14:12:32
Well Ravenstorm, before I visited the doctor doing the study I had never heard of Saredutant and it wasn't until I did a search on google that I found this forum and I believe it was a post by you or a follow up that made me decide to join.
It's a very limited study. I am in Canada and there are 2 Doctors doing the study here with about 30 patients. It is a double blind study and you either get Saredutant 100mg, Paxil 50mg?, or placebo.
It was very easy for me to figure out that I am on the saredutant because of the sideffects. Keep in mind I have never taken an antidepressant before in my life and I haven't done any drugs for well over a decade making me the perfect giniepig (sp).
When I take the pill after about 45 minutes I get this really fuzzy dreamy kind of feeling and it knocks me onto the couch. Sucks because I am supose to take the pill in the morning. There is also a mild headache that goes along with it but that fades quick.
Other sideffects are: Gas, cramps, dizzyness, dry mouth, vertigo and the list goes on. I dont get any of these but I have always had gas so it's hard to tell :)
I really dont like the feeling of apprehensivness as it kicks in (when I go fuzzy) and the best way to desribe it is (if you have ever tried it) like the feeling you get when you take XTC but really really mild but only when it is setting in. You dont walk around wanting to kiss everyone and actually I haven't really noticed any difference in my mood.
I'm afraid you would have a really hard time getting into this study because I dont think there are to many doctors worldwide taking part and you have to be in the same city as them because they monitor you like a hawk for adverse effects.
The best I can do is keep you up on my progress and hope to meet others in the study via this BBS.
Posted by ravenstorm on September 9, 2005, at 8:14:45
In reply to Re: saredutant study, posted by cncgordon on September 9, 2005, at 0:59:26
Yes, based on the side effects, you are definitely not getting the placebo. However, you could be getting paxil, not saredutant because paxil also has some pretty harsh start up side effects. (It also has some pretty harsh withdrawal symptoms for some)
Please keep us posted. If you are on paxil, will you get to try saredutant later in the study or not? Also, if you are on saredutant and it works for you, do you get to keep taking it, or do you have to stop taking it at the end of the study?
Thanks for the update, R
Posted by cncgordon on September 9, 2005, at 11:35:21
In reply to Re: saredutant study, posted by ravenstorm on September 9, 2005, at 8:14:45
It looks like 99% that I am on the saredutant because of the sideffects and the lack of Paxil like sideffects. I have the option of leaving the study at any time during the 44 weeks and then would be taken off it. DOnt know if there are withdrawl symtoms will have to wait and see.
Posted by ravenstorm on September 10, 2005, at 8:31:05
In reply to Re: saredutant study, posted by cncgordon on September 9, 2005, at 11:35:21
Interesting. Well, at least you get to stay on whatever drug you are on for a long time. Some of these studies only last 10-12 weeks.
I am curious, though, how do you know that you aren't having paxil side effects if you've never taken it before? Have they indicated that the saredutant side effects are significantly different than what paxil's would be? Also, each person reacts differently to each medication, so I would imagine it would be difficult to tell.
How long have you been taking the medication?
Posted by Tenifer on September 12, 2005, at 23:56:27
In reply to Re: saredutant study, posted by ravenstorm on September 10, 2005, at 8:31:05
cncgordon,
Thanks for thinking about us and for sharing your
experiences here. :)I'm particulary interested in this agent for
anxious depression. Is that the type of
depression you suffer from?Anyway, please keep us in mind and keep us
posted. While many don't post I would be
more than a little surprised if there
weren't many people watching this thread
for updates.Thank you and may God be with you,
David
Posted by cncgordon on September 26, 2005, at 12:13:24
In reply to Saredutant study, posted by cncgordon on September 4, 2005, at 1:30:30
After taking the drug for about a month you cant eveb notice the effects when it is setting in. I guess this is a good thing. No weight gain to speak of.
Honestly, I dont know if it is working for me.Gordon
Posted by ravenstorm on September 27, 2005, at 12:55:54
In reply to Re: Saredutant study (update), posted by cncgordon on September 26, 2005, at 12:13:24
Any sexual side effects with this drug? Sorry if this is too personal. Just trying to figure out what the side effect profile of this is compared to an SSRI. Also, how was it in terms of nausea/stomach upset?
Thanks for the update!
Posted by cncgordon on September 27, 2005, at 17:43:22
In reply to Re: Saredutant study (update), posted by ravenstorm on September 27, 2005, at 12:55:54
At first there didn't seem to be any sexual side effects but in the last few days it's kinda bad for me but it could have to do with all the problems in my relationship right now. They said to eat with the pill but I did try a few times without food and had no problems.
I am open to any questions Ravenstorm, thats what this study is all about eh
Posted by trumpet on December 23, 2005, at 13:50:14
In reply to Re: Saredutant study (update), posted by cncgordon on September 27, 2005, at 17:43:22
It is interesting to note that this same drug is being studied at a sleep clinic in Vermont by Dr. Lisa Catapano-Friedman and she is very excited about its effects thus far.
David
Posted by trumpet on December 23, 2005, at 13:54:09
In reply to Re: Saredutant study (update), posted by trumpet on December 23, 2005, at 13:50:14
I live in Louisiana and there are no local studies here. I currently and have been takin Celexa and Klonopin which are not as effective as they once were. Saredutant is the only drug I would consider taking after Celexa since I have been on the gamut of SSRI's.
Posted by trumpet on June 5, 2006, at 1:19:01
In reply to saredutant study, posted by cncgordon on September 4, 2005, at 1:36:41
cncgordon, any word on the effects of Saredutant trials and its effect on you? Thanks,
David
Posted by cncgordon on June 5, 2006, at 9:51:38
In reply to Re: saredutant study, posted by trumpet on June 5, 2006, at 1:19:01
Well, I have never taken an antidepressant before in my life so I have nothing to compare it to.
Life has been a rollercoaster but the one thing that I have noticed is that when I take omega 3 and vitimins.
Over all I think I am doing better but still not better.
The trial ends in about a month and I dont know what I will do after that. I will probably try to go drug free for a while but if that doesn't work then will have to find a substitute.
The one thing that botered me the most was not being able to concentrate. I find that it is starting to come back slowly.
Posted by trumpet on June 5, 2006, at 13:44:48
In reply to Re: saredutant study, posted by cncgordon on June 5, 2006, at 9:51:38
Thanks for the information. Please keep in touch on the thread to keep us updated. Take care,David
Posted by martinrisk on July 10, 2007, at 14:25:06
In reply to saredutant study, posted by cncgordon on September 4, 2005, at 1:36:41
Nothing like Google for finding needles [for: cncgordon post]. I am about to enter this study; since I am interested in pharmacology, I may be able to help with questions. Let me know if you are still around & interested.
You may contact me directly; please have specific subject header for easy identification [so much spam]:martinrisk@earthlink
Posted by cache-monkey on June 4, 2008, at 14:48:05
In reply to Saredutant looks like a winner, posted by Shawn. T. on July 3, 2005, at 23:07:47
I haven't been able to find anything more concrete, but the two snippets below seem to indicate that the Phase III clinicals on Saredutant did not end up showing large/significant effect sizes:
http://tinyurl.com/5ormvn
http://tinyurl.com/6oawq2This is really a shame because I also thought this one had so much promise...
Posted by cache-monkey on June 4, 2008, at 14:51:31
In reply to Saredutant doesn't look like a winner, posted by cache-monkey on June 4, 2008, at 14:48:05
Actually, here is something more concrete (from MSN) re: failure of saredutant in clinicals:
http://tinyurl.com/59nuo9
This is the end of the thread.
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