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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by zuzu80 on May 7, 2004, at 7:44:12
Hello
I am considering taking Sulpiride 50mg daily for SA. Heard that it can be helpful and gives a boost to sociability and dampenes anxiety.
Sulpiride is used at high doses 800-1200mg for the treatment of Schizophrenia. At those high doses it inhibits dopamine activity.
However, at low doses 50-150mg, it blocks dopamine's autoreceptors, and thus gives a signal to the cells to release more dopamine.
Has anyone used Sulpiride for SA? What dosage, and was it effective?
P.S. I got the feeling of the "extra" dopamine when I gave Rhodiola Rosea a try. It was very effective for anxiety and made me much more gregarious. I had to stop taking Rhodiola because I been put on Wellbutrin (for mild concentration problems).
I am considering taking Sulpiride at very low doses + 0.5mg Klonopin. I think that will give 80% relief.
Also does it lose it's effectiviness after sometime? What about side-effects?
Thanks a lot,
Christina
Posted by Michael Bell on May 7, 2004, at 16:39:14
In reply to Sulpiride for Social Anxiety? Long term use?, posted by zuzu80 on May 7, 2004, at 7:44:12
> Sorry, I didn't take Sulpiride but I did take Amisulpride. It definitely helped with negative thoughts and situational anxiety, but then pooped out after 4-5 months. I stopped taking it, then restarted about 3 months later. It had the same efficacy as when I had first started. However, I ran out of pills and the place I ordered it from ran out of stock, so I haven't been on Amisulpride since. I consider it a great additive for Social Anxiety, in combination with one of the following: adrafinil or small dose klonopin. Search the boards for other combos using sulpiride or amisulpride, as I remember there were a few people who had success with specific combos.
Side effects for me included drowsiness in for the first couple weeks, but not much else.
Hello
>
> I am considering taking Sulpiride 50mg daily for SA. Heard that it can be helpful and gives a boost to sociability and dampenes anxiety.
>
> Sulpiride is used at high doses 800-1200mg for the treatment of Schizophrenia. At those high doses it inhibits dopamine activity.
>
> However, at low doses 50-150mg, it blocks dopamine's autoreceptors, and thus gives a signal to the cells to release more dopamine.
>
> Has anyone used Sulpiride for SA? What dosage, and was it effective?
>
> P.S. I got the feeling of the "extra" dopamine when I gave Rhodiola Rosea a try. It was very effective for anxiety and made me much more gregarious. I had to stop taking Rhodiola because I been put on Wellbutrin (for mild concentration problems).
>
> I am considering taking Sulpiride at very low doses + 0.5mg Klonopin. I think that will give 80% relief.
>
> Also does it lose it's effectiviness after sometime? What about side-effects?
>
> Thanks a lot,
> Christina
Posted by Questionmark on May 8, 2004, at 23:32:54
In reply to Sulpiride for Social Anxiety? Long term use?, posted by zuzu80 on May 7, 2004, at 7:44:12
Sorry, never tried sulpiride. ...
> Hello
>
> I am considering taking Sulpiride 50mg daily for SA. Heard that it can be helpful and gives a boost to sociability and dampenes anxiety.
>
> Sulpiride is used at high doses 800-1200mg for the treatment of Schizophrenia. At those high doses it inhibits dopamine activity.
>
> However, at low doses 50-150mg, it blocks dopamine's autoreceptors, and thus gives a signal to the cells to release more dopamine.i know this is how amisulpiride works as well, but is it also the case with amantadine? i thought it was, but i can't remember for sure. Anyway, i have a prescription for (low-dose) amantadine, which i will be starting soon, so if it is also a DA autoreceptor agonist, then my experience with it might be useful for you. Unfortunately, i won't be able to give a more adequately useful account until i've been on it for awhile, since anything can happen in the first few weeks of starting a drug.
It does seem like all the dopaminergic medications not considered psychostimulants (or i.e., all the selective DAergics) completely or near-completely poop out after several months or so, however (as in Michael Bell's case with amisulpride). This is very curious to me, especially regarding why the psychostimulants still continue to work (albeit differently and/or less effectively, oftentimes) after months and months on end. Buuut, hopefully this isn't always the case.> Has anyone used Sulpiride for SA? What dosage, and was it effective?
>
> P.S. I got the feeling of the "extra" dopamine when I gave Rhodiola Rosea a try. It was very effective for anxiety and made me much more gregarious. I had to stop taking Rhodiola because I been put on Wellbutrin (for mild concentration problems).Gregarious-- nice word. i had to look it up. But yeah, Rhodiola was quite beneficial for me as well-- similar to Panax Ginseng but a good deal better. i was pleasantly surprised, too, because most herbs do not have any noticeable effects in me (e.g., St. John's Wort, Ginkgo, Kava, Valerian), despite the fact that i have very low tolerance for most (licit and illicit) "drugs." But yeah, Rhodiola was quite helpful for my anxiety (SA), sometimes had a mild euphoric effect, and also made me more pro-social ("gregarious").
> I am considering taking Sulpiride at very low doses + 0.5mg Klonopin. I think that will give 80% relief.
>
> Also does it lose it's effectiviness after sometime? What about side-effects?
>
> Thanks a lot,
> ChristinaDon't know. Good luck. and report your experiences with it. Take care.
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