Posted by trucker on April 15, 2004, at 11:07:56
In reply to Meds with Grapefruit Juice » trucker, posted by simus on April 15, 2004, at 11:01:34
soo can you drink white grapefruit juice with welbutrin and lex?????trucker
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> > white grapefruit juice before all meals, it make your chemistry change. use to eat when i wanted to loose weight a grapefruit (white only) in the am and one for lunch.. grapefruit juice as a snack inbetween and a large chef salad for supper. i lost 135 lbs in a year. nothng will taste good to ya and it changes your chemistry... also at night drink 8oz of water with a tablespoon of cider vinigar in it. it flushes the fat.. people round here wonder how i do it... its simple if ya want to do it...
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> Journal of Clin. Psychopharmacology, August 2001
> Drug Interactions With Grapefruit Juice: An Update.
> Greenblatt, David J. MD.
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> "Drug interactions with grapefruit juice will occur after a single exposure to a usual dose (such as a single 8-ounce glass). There may be variations in the extent of drug interactions depending on the source and method of preparation of grapefruit juice. Duration of exposure to grapefruit juice also is of importance. There is evidence that CYP3A inhibition may increase with repeated doses of grapefruit juice, 29 although the effect of exposure for longer than 7 to 10 days is largely unknown.
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> Public Health Implications
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> As with many issues involving the relation of prescription medications to food products or to herbal medicines, media coverage and reporting has often been excessive and unbalanced. It now is possible to evaluate the problem of grapefruit juice interactions with prescription drugs in the context of a realistic assessment of risk. Although some drugs are affected by an interaction with grapefruit juice, most are not. Individuals taking unaffected drugs may continue to take grapefruit juice with no hazard or problem. In most cases, the medications that are affected have been identified or can be predicted based on their established pathways of metabolism and pharmacokinetic properties. For patients taking medications known to interact with grapefruit juice, there generally are noninteracting alternative medications within each drug class that should allow appropriate treatment to proceed safely with no need to avoid grapefruit juice or any other as-yet-unidentified food or natural product that may interact with CYP3A through similar mechanisms. Nonetheless, it must be recognized that it will never be possible to perform a clinical study to confirm or rule out the possibility of an interaction of grapefruit juice with each and every drug that we would like to know about. Basic and clinical research on the subject will continue, and will address such questions as whether grapefruit juice influences the function of transport proteins (such as P-glycoprotein) that may contribute to determining oral bioavailability of some drugs. Ultimately, the management of actual or potential drug interactions with grapefruit juice (or with any other agent) in clinical practice requires a balance of therapeutic judgment together with a knowledge of the science."
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poster:trucker
thread:323847
URL: http://www.dr-bob.org/babble/social/20040414/msgs/336620.html