Posted by Brainbeard on November 7, 2009, at 14:37:00
In reply to Need help trying to 're-create' Geodon's effects.., posted by delna on November 1, 2009, at 10:02:53
Hi Delna,
It's a real shame that the pharmacotherapeutical love of your life caused unbearable side-effects. I was wondering wether you couldn't return to Geodon with Neurontin (gabapentin) on board this time to counter neuropathic pain, but this probably isn't a very realistic idea.
The drug I'm missing yet in this thread is cyproheptadine, which is a quite potent 5HT2C and -A antagonist. It has its own problems, though; it's short-acting, for one thing, it's antihistaminergic and anticholinergic, and it appears to worsen depression in some people who take it along with an (S)SRI. Since it's dirt cheap, it might be worthwhile trying.
Because of Geodon's complex pharmacological actions, it's hard to know what mechanism(s) exactly worked like a charm for you. It might not be the 5Ht2C-antagonism at all. It could be its 5HT7-antagonism, which appears to be a powerful antidepressant mechanism according to newer research. Another drug that does that trick is amisulpride/Solian. Amisulpride makes prolactin levels go through the roof, but that may be less of a direct problem for a girlie like yourself.
I mean, with daily use it made my titties grow, which I didn't find particularly sexy.I have pondered combining Prozac with cyproheptadine as a means of achieving a lot of 5HT2C-antagonism for my buck.
Mirtazapine (Remeron) is in fact a very strong 5HT2C/A-antagonist, and when taken in higher doses it might be more activating. Still, most people seem to become sleepy, horny and fat on it, which may not be an accurate description of your ideal profile.
I myself have had fairly good results with 50mg of amitriptyline, another antihistaminergic 5HT2A/C-antagonist, combined with 25mg of imipramine. Once I got used to the antihistaminergic effects, I wasn't sedated anymore, and the imipramine also peppered things up.
Agomelatine, despite its weak affinity for 5HT2C receptors, may be interesting for you after all since it is said to restore normal sleeping patterns.
Indeed, as mentioned above, Tramadol is another lesser known 5HT2C-antagonist, though its affinity in this area is unknown to me. It is also, like Geodon, a moderately strong (or weak) SNRI - I personally think its noradrenergic action is more pronounced, since it comes across to me as a mix between a mild opiate and speed. It's a rather effective antidepressant for many - it is chemically very similar to Effexor. It can be pretty stimulating, like Geodon in the lower dose range. But it also has its problems - it is strongly dependence forming, possibly addictive, there may be a problem with tolerance and then I have also heard rumours of it possibly causing neuropathic pain in the longer term, which is odd since it it supposed to help with that.
So yeah - uhuh. Not that much to go on, I'm afraid. Some dead ends, some options. Keep us posted if you like.
Good luck!
poster:Brainbeard
thread:923807
URL: http://www.dr-bob.org/babble/neuro/20091104/msgs/924872.html