Posted by undopaminergic on June 3, 2008, at 9:55:35
In reply to Re: What are some dopameric and/or noradrengeric med? » undopaminergic, posted by rgb on June 3, 2008, at 7:22:03
> Sertraline is also somewhat dopaminergic; I seem to remember that its DAT affinity is roughly 1% of its SERT affinity. This doesn't sound all that bad (theoretically!) if you consider that SERT is saturated at low-ish doses and you don't need to nearly-saturate DAT.
>Well, 40 mg methylphenidate yields about 70% DAT inhibition, and it's really not sufficient in my experience. With sertraline even such a modest extent of inhibition is infeasible. If you can get methylphenidate, modafinil, cocaine, or one of the many less popular DAT inhbitors, there's no reason to attempt to exploit the weak DAT blockade of sertraline.
> With this in mind, I actually /increased/ my dose to 200mg and later to 300mg and on a few days even 400mg in an attempt to counter residual amotivation (don't try this at home.).
>
> This even worked to some degree, though the increases felt more like a slight "awareness broadening" (5-HT2-esque) effect, no reinforcing/reward-type effect. Whatever it was, unfortunately I've mostly built tolerance to it and am mostly back in brain-fog-land. Go to 400mg permanently? (kidding ;)) My wild guess is that it's 5-HT2A downregulation; is there some way to counter this?
>5-HT2A antagonists would probably counter it, but of course, the pharmacological effect of that would be equivalent to downregulation, until the antagonist is stopped, but at that point downregulation would again commence. There may be no way to eat the cake and have it too.
poster:undopaminergic
thread:828365
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/832663.html