Posted by cumulative on April 30, 2008, at 6:38:14
In reply to Antibodies against muscarinic cholinergic receptor, posted by iforgotmypassword on April 28, 2008, at 17:10:06
hi,
Antibodies, jeez.
I am going to summarize for you some quite theoretical (the disease lies in shadow, unfortunately) ideas that both I and many of the researchers in this matter have been examining. I hope this helps instead of confuses:
excessive glutamate/NMDA activity (from any number of sources) <---> potentiates muscarinic acetylcholine <---> potentiates histamine, inflammation and the excessive expression of immune factors ... some form of autoimmune activity is typical
This relationship works backwards and forwards.
CFS strikes me as a disease with a very large number of possible etiologies and/or causes ... probably in any single CFS patient there may be a number of issues that have contributed to the very difficult state that the person now finds themselves in.
Some probable contributors:
- Constant sleep deprivation
- Heavy exposure to allergic triggers
- Lack of stress control
- Poor diet
- Gluten?
- Dopamine plays a various but often inhibitory role at every point within the above-mentioned
neurotransmitter relationship, and vice versa -- glutamate, muscarinic acetylcholine, histamine. Perhaps this relates to your feelings of comparison (maybe even a spectrum) between CFS and atypical depression, anhedonia, indecision, etc., yes?
- Any number of these issues might encourage underlying viral infections, and pathological autoimmune responses to said infections, if we are to follow the research implicating those problems.Take magnesium,
cumulative
poster:cumulative
thread:826103
URL: http://www.dr-bob.org/babble/neuro/20080418/msgs/826376.html