Posted by Mtom on July 12, 2020, at 19:00:07
A few Review Studies finding positive results of Probiotics on Depression:
Gut feeling: randomized controlled trials of probiotics for the treatment of clinical depression: Systematic review and meta-analysis Published June 2019 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595633/
Three studies were reviewed. Two found significant differences in Beck Depression Inventory after 8 weeks of add-on probiotics to antidepressants: -5.7 vs -1.5 in placebo and -9.25 vs -3.19 in placebo. The 3rd study found no difference but used different recruitment protocol, did not assess on a diagnostic scale at baseline, and participants were not taking ADs. Details of probiotic species and doses in the article.The effects of probiotics on depressive symptoms in humans: a systematic review Published Feb 2017 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319175/
This review of previous studies found that the included studies demonstrate that it is likely that daily consumption of a probiotic supplement could have a positive effect in improving the mood, anxiety, and cognitive symptoms present in MDD. The majority of the studies found positive results with no serious adverse events being reported. It appears that probiotics may have the most significant effect on symptoms of anxiety, which is often co-morbid with MDDAntidepressive Mechanisms of Probiotics and Their Therapeutic Potential published Jan 2020 https://www.frontiersin.org/articles/10.3389/fnins.2019.01361/full
Another review that goes into some detail about the hypothetical antidepressive mechanisms behind various species and strains.
As these were review studies, links to the individual studies reviewed can be found in the webpages above. Some give details of the types and amounts of probiotic species and strains used.
poster:Mtom
thread:1111255
URL: http://www.dr-bob.org/babble/alter/20190907/msgs/1111255.html