Posted by sregan on August 28, 2010, at 20:06:58
In reply to Re: Chromium GTF producing a definite effect on depres, posted by islan on August 20, 2010, at 23:08:08
The Chromium is working for me @ 100 mcg in the morning it does a very good job of lifting my mood and lasts for a while. One might experiment with their own dosage....I read a article where they used 400mcg per day for depressed patients.
This study (www.if-pan.krakow.pl/pjp/pdf/2008/6_991.pdf)
reports this:In summary, the present study demonstrates the
antidepressant-like activity of Cr in the mouse FST
and indicates the major role of the AMPA receptor
and participation of NMDA glutamatergic and 5-HT
1A and 5-HT 2A/C serotonin receptors in this activity.I had already read that Chromium acts to downregulate 5HT2A
Also read this from: ROBERT N. GOLDEN, M.D, Professor and Chair of Psychiatry
Vice Dean, University of North Carolina
"Chromium is only in its first chapter; so far, so good, but we need many more controlled clinical trials before we can be confident of its efficacy. There are 2 theories regarding potential mechanisms of action. Animal and human data show chromium increases serotonergic function. Second, we know that chromium increased the efficiency of glucose utilization, and this might be very important in the brain, where glucose is the sole source of energy production. Attenburrow, et al showed that in rats, chromium increased peripheral and central tryptophan availability and elevated 5-HT content in the brain. In humans, chromium lowered the cortisol response to challenge 5-HTP. Furthermore, a double-blind pilot study by Davidson, et al shows chromium is useful and well tolerated in patients with symptoms of atypical DSM-IV major depressive disorder. Its mechanism may relate to 5HT2A downregulation or increased insulin sensitivity. Three simultaneous studies in rats by Franklin and Odontiadis lean toward enhancement of monoamine function. Chromium significantly increased serum free tryptophan, non-esterified free fatty acids, corticosterone with brain tryptophan, serotonin, noradrenaline, and pineal melatonin."> >> "I've read a lot about Chromium helping Atypical depression so I'm giving it a try."
>
> I have not tried this but I'm interested in how your experience is going.
>
> After having a major depressive episode I spent 5 years on SSRIs and experienced intense hunger and tiredness for most of that time, symptoms of what they call "atypical depression" (well when they occur in depressed people!).
>
> I didn't understand why (a) the meds combined with all my therapy and yoga etc. were not fixing my depression, or (b) this hungry sleepy manifestation of depression was not the one usually described in pamplets (loss of sleep and appetite being more common).
>
> I wondered if Chromium would help but I didn't know where to get it, didn't see it in the vitamin aisle... Anyway my GP switched me onto SNRIs this Spring, and since then my appetite has been MUCH lower and my energy has gotten a bit better - I started taking vitamin B around the same time though, which probably also factored in.
>
> So yeah I wanted to share and ask how the chromium is working out for you, I'm still looking for energy boosters. Best of luck and thanks for posting!
poster:sregan
thread:958439
URL: http://www.dr-bob.org/babble/alter/20100812/msgs/960368.html