Posted by Ron Hill on March 25, 2010, at 17:19:51
In reply to Re: SUCCESS! - Phenylethylamine (PEA) » Ron Hill, posted by Economist on March 24, 2010, at 10:07:33
> Is taking the full 250 mg of PEA with low dose selegiline too much? The original poster said he took 500 mg.
Economist,
This is a long post, but stick with me. I think it will be worth your time.
The two links immediately below are abstracts. Please read both of them prior to reading further in this post.
Abstract #1:
Abstract #2:
Okay. Next, we need to find a way to access the Full Text versions for both of these abstracts. However, doing so is not straight forward because the Journal of Neuropsychiatry and Clinical Neurosciences does not offer free access to their Full Text versions. Therefore, since we cannot go through the front door, we will go through a back door to gain access to the Full Text versions.Here is the gist of our method: There exists a Full Text version of a study that explores the correlation between exercise and endogenous levels of PEA. As it turns out, the two Full Text documents that we are looking for are references at the bottom of the Exercise document. Better still, the references have hot-links.
The last thing I need to tell you is that access to the Exercise document requires you to complete a free registration form. Okay, let's do it:
1. Click here: http://bjsm.bmj.com/cgi/content/full/35/5/342
2. Click on the Free Registration link.
3. Fill out the Free Registration form and, when you are done, you will more than likely be automatically routed to the full text version of the Exercise article. If so, skip Steps 4 and 5 below. If not, follow the instructions in Steps 4 and 5 below to pull-up the Exercise document.
{4.} Click here: http://bjsm.bmj.com/cgi/content/full/35/5/342
{5.} Fill in your user name and password that you specified when you registered. The full text of the Exercise article will come up on your screen.
6. Scroll down until you get to the References section at the bottom of the Exercise full text article. Now we have arrived at the back door. The two articles we want are Reference #2 and Reference #3. Click on one of them.
7. The abstract of the article will come up. In the menu box on the right hand side of the page, (directly adjacent to the abstract text), click the Full Text(PDF)link.
8. If you are patient, the pdf text will come up in a minute or so. If youve got ants in your pants, you can save 30 seconds or so by clicking [Begin manual download].
9. Read the Full Text pdf article, and print it if you wish. Then return to the list of references at the bottom of the Exercise article, and repeat the process for the other hot-link.
10. If you have time, read the exercise document (a.k.a.; "Phenylethylamine, a possible link to the antidepressant effects of exercise?")
As you know, at 10 mg/day, selegiline is a selective MAOI-B. However, at higher selegiline daily dosages, it is an MAOI-A and an MAOI-B (i.e.; non-selective).
In accordance with the study that you just read, it appears that 60 mg/day of PEA is safe to take with 10 mg/day of selegiline. However, at higher dosages of selegiline, 60 mg/day of PEA might cause problems; like a hypertensive crisis. However, everyone is different.
When I conducted a PEA trial a couple years ago, I took 13 mg/day of PEA with my usual 90 mg/day of Nardil. As soon as I took my first dose of PEA, my blood pressure immediately jumped from my usual 110/70 to 142/84 and it stayed there throughout my PEA add-on trial.
So, for what it is worth, my recommendation is to start low and go slow if you plan to add PEA to a non-selective MAOI.
Monitor your blood pressure. Do you have a blood pressure measuring machine? Do you carry a hypertensive antidote (e.g.; nifedipine) with you at all times? IMHO, everyone taking an MAOI should have both.
Rule #1: Nobody gets hurt!
Rule #2: Don't forget Rule #1!!-- Ron
dx: Bipolar II with ultra rapid cycling, and mild OCPD
600 mg/day Trileptal
200 mg/day Lamictal
500 mg/day Keppra
90 mg/day Nardil
1.9 mg/day Deplin (taken with methyl B-12 and P-5-P)
Dark therapy via LowBlueLight glasses
High dosage of fish oil, 300 mg/day phosphatidylserene, and several other vitamins and supplements
poster:Ron Hill
thread:937976
URL: http://www.dr-bob.org/babble/alter/20100322/msgs/940832.html