Posted by morganpmiller on June 24, 2009, at 15:29:36
In reply to Re: N-acetylcysteine and OCD, posted by morganpmiller on June 24, 2009, at 15:21:30
You can take your resveratrol with your whey protein as some of the resveratrol will bind to the beta lactoglubin in the whey. This is a good thing.
Resveratrol may help in other ways that could treat OCD.Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptamine uptake and on monoamine oxidase activitystar, open
Purchase the full-text article
Received 27 February 2006.
Available online 17 April 2006.Abstract
This study investigated for the first time the potential effects of cis- and trans-resveratrol (c-RESV and t-RESV) on noradrenaline (NA) and 5-hydroxytryptamine (5-HT) uptake by synaptosomes from rat brain, on 5-HT uptake by human platelets, and on monoamine oxidase (MAO) isoform activity. Both c-RESV and t-RESV (5200 μM) concentration-dependently inhibited the uptake of [3H]NA and [3H]5-HT by synaptosomes from rat brain and the uptake of [3H]5-HT by human platelets. In both experimental models, t-RESV was slightly more efficient than c-RESV. Furthermore, in synaptosomes from rat brain, the RESV isomers were less selective against [3H]5-HT uptake than the reference drug fluoxetine (0.130 μM). On the other hand, both c-RESV and t-RESV (5200 μM) concentration-dependently inhibited the enzymatic activity of commercial (human recombinant) MAO isoform (MAO-A and MAO-B) activity, c-RESV being slightly less effective than t-RESV. In addition, both RESV isomers were slight but significantly more selective against MAO-A than against MAO-B. Since the principal groups of drugs used in the treatment of depressive disorders are NA/5-HT uptake or MAO inhibitors, under the assumption that the RESV isomers exhibit a similar behaviour in humans in vivo, our results suggest that these natural polyphenols may be of value as structural templates for the design and development of new antidepressant drugs with two important biochemical activities combined in the same chemical structure: NA/5-HT uptake and MAO inhibitory activity.
poster:morganpmiller
thread:887620
URL: http://www.dr-bob.org/babble/alter/20090410/msgs/902974.html