Posted by desolationrower on February 23, 2009, at 23:01:11
In reply to Re: Natural anticonvulsants? » desolationrower, posted by SLS on February 23, 2009, at 20:38:33
interesting, this is what i know, maybe something new that can help:
in serotonin syndrome one factor is nmda activation because of 5ht2 activation, i think colocalised, i think this might be why memantine blocks ss. there is actually mixed evidence on 5ht2a downregulation with ssris, i came across more studies later today. i think 5ht3 is involved in glutamate efflux (memantine antagonises 5ht3 too). natural 5ht3 antagonists include ginger, korean red ginsing.have you thought about the reverse of proposed first-week anxiety/dysphoria because the increased extracellular 5ht hits the autoreceptors and reduces firing (eg, low 5ht levels and high firing)? this sounds not like ss.
venlafaxine withd was bad it felt like a flu - nausea, headache, vertigo, tinnitus/buzzing (i think this is 'shocks' people describe). tinnitus in particular, and 5ht sensory gating function is thouht to play a role. nausea, 5ht3 is known to be involved.
-d/r
poster:desolationrower
thread:881348
URL: http://www.dr-bob.org/babble/alter/20090204/msgs/882077.html