Posted by Netch on December 19, 2007, at 8:14:38 [reposted on December 23, 2007, at 7:35:20 | original URL]
In reply to Alpha lipoic acid: different forms?, posted by linkadge on December 18, 2007, at 22:38:37
"R-Lipoic acid is much more potent (2 times on average) than commonly sold synthetic lipoic acid which contains both the R and S forms of lipoic acid. The S form is chemically the mirror image of the R form of lipoic acid and cannot be used by the body, hence it is useless. Thus, 50 mg of R-Lipoic Acid is equivalent to 100 mg of synthetic lipoic acid. "
http://www.raysahelian.com/lipoic.html
"Normally, only the R-enantiomer of lipoic acid occurs naturally, but the S-enantiomer can assist in the reduction of the R-enantiomer when a racemic mixture is given.[27] However, some recent studies have suggested that the S-enantiomer in fact has an inhibiting effect on the R-enantiomer, reducing its biological activity substantially and actually adding to oxidative stress rather than reducing it. Furthermore, the S-enantiomer has been found to reduce the expression of GLUT4, responsible for glucose uptake in cells, and hence to reduce insulin sensitivity"
http://en.wikipedia.org/wiki/Lipoic_acid
/Netch
poster:Netch
thread:802193
URL: http://www.dr-bob.org/babble/alter/20071031/msgs/802194.html