Posted by circusboy on September 4, 2007, at 15:04:53
In reply to TMG - SAMe, posted by Jamal Spelling on September 1, 2007, at 7:40:18
On Larry's (indirect -- found by searching through old threads) advice, I tried TMG after a very long (4-5 months) and moderately successful trial of SAMe.
My experience: it works as well as SAM-e, but takes much longer. After 500mg/day for a month (it only took about 7 days with SAM-e), I started to feel more motivated, had more mental energy, etc. Unfortunately, I also felt the downsides: blunted sense of humor, diminished creativity, and increased blood pressure.
I find that 400mcg/day of folic acid does nearly as well, but without the downsides (though I still have to quit the folic acid for a couple of days a week to keep my heart rate/blood pressure down). I should also point out that SAM-e helped pull me out of an awful anergic depression. I'm very glad it was available when I needed it, but it turned out not to be the best long-term solution.
If I feel "undermethylated" (in quotes not because I don't think such a condition exists, but because I don't know enough to say for sure it's the cause of my anergia) in the future, however, it's the bottle of TMG I'll reach for, not the blister pack of SAM-e.
-cb
P.S. - I do plan to post about my current regimen soon... hopefully it will be helpful.
poster:circusboy
thread:780153
URL: http://www.dr-bob.org/babble/alter/20070816/msgs/780797.html