Posted by djmmm on November 7, 2005, at 20:55:14 [reposted on November 8, 2005, at 23:26:11 | original URL]
In reply to Gamibetal-Possible GHB replacement?, posted by Tom Twilight on November 7, 2005, at 16:55:29
> Hey everyone
>
> I got the information about Gamibetal from a post by someone called jparsell82 on the alternative board.
>
> I'm always on the look out GABA analogues and GHB like substances that cross the blood brain barrier.
> I generally find them more helpful than benzo's for my social anxiety, which I find difficult to treat.
> The best GABA analogue I've found is Phenibute, but it does have drawbacks.
> Does anyone have any experience of info about Gamibetal?
>
> It should be noted that I'm not stating that GHB is 'safe', only that I found it helpful
>
> Here is the info that jparsell82 posted
>
> Posted by jparsell82 on October 31, 2005, at 15:17:43
>
> Aminohydroxybutyric acid is otherwise known as GABOB, Gamibetal or
> Buxamin and is related to GABA and also to GHB.
>
> This rarely found supplement has been in published literature since the
> 1960's, and its uses in Europe have been for its anti-anxiety,
> anti-stress purposes and also for its anti-convulsion actions in Epilepsy.
>
> What is very interesting is that since the 1980's it has been known
> that Aminohydroxybutyric acid can increase growth hormone levels. One
> study, (Melis GB et al: Dose related effects of gamma-amino beta-hydroxy
> butyric acid [GABOB] infusion on growth hormone secretion in normal
> women: J. Endocrinol. Invest., 1982 Mar-Apr;5(2):101-6) found that when
> women were infused with 100 mg. over 20-minutes that there was a
> significant rise in HGH levels over their controls. This helped back up an
> earlier study, (Fioretti P. et al. Gamma-amino-beta-hydroxy butyric acid
> stimulates Prolactin and growth hormone release in normal women. J. Clin.
> Endocrinol. Metab. 1978 Dec;47(6):1336-40), that also suggested that 100
> mg. of aminohydroxybutyric acid i.v. increased HGH and Prolactin
> levels.
>
> Significant improvements to HGH, Prolactin and cortisol levels have
> also been noted in men who were injected with 300 mg. of
> Aminohydroxybutyric acid, (Takahara J et al. Stimulatory effects of
> gamma-aminohydroxybutyric acid [GABOB] on growth hormone, Prolactin and cortisol release in
> man).
>
> What makes all this significant is that these agonist (stimulatory)
> effects of Aminohydroxybutyric acid are very similar to GHB, and whilst
> the injectable versions have induced unconsciousness at dosages over 150
> mg., it does not appear to do so when used orally, (this was the main
> reason why GHB banned as it can induce unconsciousness when taken orally
> and was used by nefarious males for date-rape).
>
> Therefore, this is why we believe that as Aminohydroxybutyric acid is
> related to GHB and shares many of its properties; it is in fact the
> closest legal molecule/ alternative available.
>
> There are no reported side effects at normal dosages. At high dosages
> some slight drowsiness may occur, therefore caution is advised to be in
> a safe environment, (i.e. not driving or operating machinery etc).
>
> There are no specific contraindications listed, although concurrent use
> with other GABA supplements and agonists (i.e. Valium) is not advised
> and would be best considered only under a physician's guidance.
>
> Dosages for anti-anxiety/ stress would be in the region of 250 mg. once
> or twice daily. For epilepsy 500 mg. twice daily. For HGH release,
> (whilst this does still remain “experimental” in oral form), in the region
> of 500 mg. to 1000 mg. prior to bedtime.
>I tried aminohydroxybutyric acid. It's one of 3 ingredients in the supplement Gamalate B6 (GABOB, GABA, B6) It didn't do much of anything..at any dose..
poster:djmmm
thread:573832
URL: http://www.dr-bob.org/babble/alter/20051025/msgs/576973.html