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Re: SAM-e combination

Posted by Declan on July 8, 2005, at 21:52:26

In reply to Re: SAM-e questions, posted by jessers11581 on July 2, 2005, at 14:29:25

I thought you might be interested in my experience with Parnate and SAMe. I've been on Parnate 10mg/d (1 tablet) and 400mg SAMe, both of which I took first thing am.
To begin with it was good, I had an immediate and strong response to the Parnate. (I've been on SAMe for ages.) After the second or third day though, I got feelings of agitation/irritation/anger. Today is the first day off the SAMe and I feel much better. I wondered if the combination was somehow stimulating one of those 5ht2 receptors that Linkadge has been on about. Cymbalta is probably quite different but you might keep an eye out for that sort of thing. To begin with I was reluctant to give up the SAMe (liver, arthritis) and was going to take only 1/2 a tablet of Parnate/d. However I managed to be flexible.
Declan


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