Posted by Jakeman on June 19, 2005, at 14:47:40
In reply to Re: great news, posted by linkadge on June 19, 2005, at 5:25:56
Link, thanks for the info. Quercetin also appears to reverse cognitive impairment caused by age or alchohol consumption.
~JFree Radic Res. 2003 Nov;37(11):1245-52. Links
Reversal of aging and chronic ethanol-induced cognitive dysfunction by
quercetin a bioflavonoid.Singh A, Naidu PS, Kulkarni SK.
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab
University, Chandigarh-160014, India.Cognitive dysfunction, one of the most striking age-related impairments seen in
human beings, has been correlated to the vulnerability of the brain to
increased oxidative stress during aging process. Quercetin is a bioflavonoid
with strong antioxidant properties. Experiments were performed to study the
possible effects of quercetin on cognitive performance of young, aged or
ethanol-intoxicated mice (an animal model for cognition dysfunction) using one
trail step down type of passive avoidance and elevated plus maze tasks,
respectively. Aged or chronic ethanol-treated mice showed poor retention of
memory in step-down passive avoidance and in elevated plus-maze task. Chronic
administration of quercetin (10, 25 and 50 mg/kg) for 30 days or its
co-administration with ethanol (15% w/v, 2g/kg per orally) for 24 days
significantly reversed the age-related or chronic ethanol-induced retention
deficits in both the test paradigms. However, in both memory paradigms chronic
administration of quercetin failed to modulate the retention performance of
young mice. Chronic quercetin administration for 30 days also reversed age
associated increase in TBARS levels and decline in forebrain total glutathione
(GSH), SOD and catalase levels. Chronic ethanol administration to young mice
produced an increase in lipid peroxidation, and a decline in forebrain total
glutathione (GSH), SOD and catalase levels, which was significantly reversed by
the co-administration of quercetin (10, 25 and 50 mg/kg). The results of the
present study showed that chronic quercetin treatment reverses cognitive
deficits in aged and ethanol-intoxicated mice, which is associated with its
antioxidant property.
poster:Jakeman
thread:515377
URL: http://www.dr-bob.org/babble/alter/20050612/msgs/515550.html